Cytokine Genotyping in Preeclampsia
Article first published online: 19 JAN 2006
American Journal of Reproductive Immunology
Volume 55, Issue 2, pages 130–135, February 2006
How to Cite
Daher, S., Sass, N., Oliveira, L. G. and Mattar, R. (2006), Cytokine Genotyping in Preeclampsia. American Journal of Reproductive Immunology, 55: 130–135. doi: 10.1111/j.1600-0897.2005.00341.x
- Issue published online: 19 JAN 2006
- Article first published online: 19 JAN 2006
- Submitted June 20, 2005; revised October 6, 2005; accepted October 25, 2005.
- gene polymorphism;
Problem Considering that cytokines are involved in preeclampsia (PE) pathogenesis and that cytokine gene polymorphism may affect cytokine production, our purpose was to investigate the association of PE with tumor necrosis factor (TNF)-α (−308), transforming growth factor-β1 (+10; 25), interleukin (IL)-10 (−1082), IL-6 (−174), and interferon-γ (+874) polymorphisms.
Method of study Genotyping was performed in women with PE (56 White and 95 non-White women) and in women without obstetric pathology (92 White and 97 non-White women). Data were analyzed by the chi-square or Fisher exact test. We performed a meta-analysis encompassing these and results from other laboratories on the association of TNF-α polymorphisms and PE.
Results We observed a lower frequency of the IL-10 −1082-G/G genotype in White women with PE (PE: 5%; Control (C): 15%, P = 0.02) and no association for all other polymorphisms, including meta-analysis of TNF-α results.
Conclusion Our study suggests that PE is associated with IL-10-(1082) polymorphism but not with TNF-(308) polymorphism. On the basis of meta-analysis, we confirm the need for more studies for the evaluation of cytokine genotype in disease.