High Levels of Peripheral Blood NK Cells in Women Suffering from Recurrent Spontaneous Abortion are Reverted from High-Dose Intravenous Immunoglobulins
Article first published online: 1 FEB 2006
American Journal of Reproductive Immunology
Volume 55, Issue 3, pages 232–239, March 2006
How to Cite
Perricone, R., Muzio, G. D., Perricone, C., Giacomelli, R., Nardo, D. D., Fontana, L. and Carolis, C. D. (2006), High Levels of Peripheral Blood NK Cells in Women Suffering from Recurrent Spontaneous Abortion are Reverted from High-Dose Intravenous Immunoglobulins. American Journal of Reproductive Immunology, 55: 232–239. doi: 10.1111/j.1600-0897.2005.00356.x
- Issue published online: 1 FEB 2006
- Article first published online: 1 FEB 2006
- Submitted September 23, 2005; accepted December 5, 2005.
- Cytokine balance;
- IVIG therapy;
- spontaneous abortion
To determine the levels of peripheral blood natural killer (NK) cells in healthy women and recurrent aborters, and the effect of intravenous immunoglobulins (IVIGs) on these levels.
Method of study
A total of 659 women were evaluated for NK cells by means of flow cytofluorimetry: 42 non-pregnant healthy women, 394 non-pregnant recurrent spontaneous abortion (RSA) women, 36 pregnant healthy women and 187 pregnant RSA women. Fifty-four of the pregnant RSA women were treated with IVIG; in 18 of them NK cells were measured immediately before and after the very first IVIG infusion (0.5 g/kg body weight).
Blood NK cell results were increased in RSA pregnant/non-pregnant women, and significantly reduced by IVIG, even after the very first infusion. In RSA pregnant women treated by means of IVIG therapy, 92.3% success rate was observed.
High levels of NK cells are detected in women affected by RSA. IVIGs are capable of decreasing them with a short- and long-term efficacy, allowing having a very high success rate of pregnancies in RSA women.