Preeclampsia: the Death of Goliath

Authors


Bruce B. Feinberg, Women's Health Associates, 101 Prospect Street, Suite 202, Lakewood, NJ 08701, USA.
E-mail: bfeinberg@sbhcs.com

Abstract

In this review, a novel and unifying pathophysiologic mechanism of preeclampsia is presented whereby a minimal excess of placental immune complex production versus removal causes a proinflammatory autoamplification cascade of trophoblast apoptosis/necrosis and oxidative stress, culminating in clinical preeclampsia. This concept immediately leads to a plethora of new and robust therapeutic strategies.

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