Impact of Microbicides and Sexually Transmitted Infections on Mucosal Immunity in the Female Genital Tract
Article first published online: 31 OCT 2006
American Journal of Reproductive Immunology
Volume 56, Issue 5-6, pages 356–363, November/December 2006
How to Cite
Keller, M. J. and Herold, B. C. (2006), Impact of Microbicides and Sexually Transmitted Infections on Mucosal Immunity in the Female Genital Tract. American Journal of Reproductive Immunology, 56: 356–363. doi: 10.1111/j.1600-0897.2006.00436.x
- Issue published online: 31 OCT 2006
- Article first published online: 31 OCT 2006
- Submitted 15 August, 2006; accepted 18 September, 2006.
- Genital herpes;
- human immunodeficiency virus;
- mucosal immunity
Human immunodeficiency virus, genital herpes, and other sexually transmitted infections are a critical national and global health priority requiring the rapid development of safe and effective control methods. Topical microbicides, self-administered agents designed for vaginal use, that block transmission at the mucosal surface may provide a realistic method of intervention that could be distributed worldwide. An optimal microbicide should protect against infection but must also be safe, without adversely affecting the mucosal environment, including mediators of host defense. Thus, a critical component in microbicides development is to identify optimal assays that could serve as surrogate markers to predict safety of microbicides prior to embarking on large-scale clinical trials. This will require a greater understanding of the mediators of mucosal immunity in the female genital tract.