Controlled Ovarian Hyperstimulation Changes the Prevalence of Serum Autoantibodies in In Vitro Fertilization Patients
Article first published online: 31 OCT 2006
American Journal of Reproductive Immunology
Volume 56, Issue 5-6, pages 364–370, November/December 2006
How to Cite
Haller, K., Sarapik, A., Talja, I., Salumets, A. and Uibo, R. (2006), Controlled Ovarian Hyperstimulation Changes the Prevalence of Serum Autoantibodies in In Vitro Fertilization Patients. American Journal of Reproductive Immunology, 56: 364–370. doi: 10.1111/j.1600-0897.2006.00438.x
- Issue published online: 31 OCT 2006
- Article first published online: 31 OCT 2006
- Submitted 7 July, 2006; accepted 21 September, 2006.
- Common autoantibodies;
- supraphysiological sex hormone levels
Problem Autoimmune mechanisms are involved in etiology of female infertility, the medical problem frequently treated by in vitro fertilization (IVF). Controlled ovarian hyperstimulation (COH) with supraphysiological levels of sex hormones is achieved by IVF.
Methods of study Anti-human-ovary and eight common autoantibodies [nuclear (ANA-H, ANA-R on human HEp-2 cell line and rodent antigen, respectively), smooth muscle (SMA), parietal cell, thyroid microsomal, mitochondrial, β2-glycoprotein-I, cardiolipin antibodies] found in IVF patients (n = 129) were analyzed with regard to the number of previous IVF procedures and the age of the patient. The changes in autoimmune reactions caused by the COH were determined.
Results Endometriosis and polycystic ovary syndrome were associated with a higher number of common serum autoantibodies compared with the tubal factor infertility (Proportion test, P < 0.05). ANA-R was associated with unexplained infertility [adjusted odds ratio (aOR) 8.79, P = 0.038]. SMA correlated with endometriosis (aOR 37.29, P = 0.008), male factor infertility (aOR 20.45, P = 0.018) and with the previous IVF procedures (aOR 2.87, P = 0.013). There was an overall decrease in the number of detectible autoantibodies after COH (Proportion test, P < 0.05).
Conclusion COH may have a suppressive effect on the humoral immunity by the time of embryo transfer but more conclusive studies are needed.