Could the Defects in the Endometrial Extracellular Matrix During the Implantation Be a Cause for Impaired fertility?
Version of Record online: 8 DEC 2006
American Journal of Reproductive Immunology
Volume 57, Issue 1, pages 40–48, January 2007
How to Cite
Skrzypczak, J., Wirstlein, P. and Mikolajczyk, M. (2007), Could the Defects in the Endometrial Extracellular Matrix During the Implantation Be a Cause for Impaired fertility?. American Journal of Reproductive Immunology, 57: 40–48. doi: 10.1111/j.1600-0897.2006.00443.x
- Issue online: 8 DEC 2006
- Version of Record online: 8 DEC 2006
- Submitted June 16, 2006 revised September 25, 2006; accepted October 12, 2006.
- metalloproteinase 9;
- tissue inhibitor of metalloproteinases 1;
- uterine fluid
Assessment of concentration of the metalloproteinase 9 (MMP9), tissue inhibitor of metalloproteinases 1 (TIMP1), urokinase plasminogen activator (uPA) and its receptor (uPAR) and leukaemia inhibitory factor (LIF) in the uterine fluid in women with idiopathic infertility and unknown cause for recurrent miscarriage.
Method of study
Uterine fluid obtained from patients with idiopathic infertility (n = 13), patients with unknown cause of recurrent miscarriages (n = 16) and healthy fertile women (n = 14). The assessment of MMP9, TIMP1, uPA, uPAR and LIF were performed with enzyme-linked immunosorbent assay.
Statistically lower expression of MMP9 and TIMP1 in uterine fluid during implantation window in women with infertility and recurrent miscarriage of unknown cause.
Changed turnover of the extracellular matrix might be a cause of improper endometrial transition and in effect cause faulty implantation.