Local Markers for Prediction of Women at Higher Risk of Developing Sequelae to Chlamydia trachomatis Infection
Article first published online: 8 JAN 2007
American Journal of Reproductive Immunology
Volume 57, Issue 2, pages 153–159, February 2007
How to Cite
Agrawal, T., Vats, V., Salhan, S. and Mittal, A. (2007), Local Markers for Prediction of Women at Higher Risk of Developing Sequelae to Chlamydia trachomatis Infection. American Journal of Reproductive Immunology, 57: 153–159. doi: 10.1111/j.1600-0897.2006.00459.x
- Issue published online: 8 JAN 2007
- Article first published online: 8 JAN 2007
- Submitted August 31, 2006; revised November 15, 2006; accepted November 15, 2006.
- C-reactive protein;
- chlamydia heat-shock proteins 60 and 10;
- Chlamydia trachomatis;
- local markers
Chlamydial infections are often associated with various fertility-related disorders. Serological prediction of these has limitations, as they do not differentiate between past and current infections. Thus, we looked for local markers that could predict more precisely women at higher risk of developing severe complications.
Method of study
A total of 320 Chlamydia trachomatis positive women with or without fertility disorders were tested for the prevalence of immunoglobulin A antibodies to synthetic peptides of chlamydial heat-shock protein 60 (cHSP60) and cHSP10 along with cervical interferon-gamma (IFN-γ) and serum C-reactive protein (CRP) levels.
Positive IFN-γ level was the single best predictor for fertility disorder [odds ratio (OR) 15.4]. The predictive value of IFN-γ could be significantly improved only by the addition of CRP test (OR 37.9).
Positive IFN-γ levels in cervical washes along with elevated CRP levels could be used to predict women who are at higher risk of developing fertility disorders.