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Variations in Cervical IL-10 and IL-8 Concentrations Throughout Gestation in Normal Pregnancies

Authors

  • Myriam Mondestin-Sorrentino,

    1. Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, Jersey Shore University Medical Center, Neptune, NJ, USA
    2. Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA
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  • John C. Smulian,

    1. Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA
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  • Anthony M. Vintzileos,

    1. Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA
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  • David Sorrentino,

    1. Department of Neonatology, Saint Christopher's Hospital, Philadelphia, PA, USA
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  • Cande V. Ananth,

    1. Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA
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  • Surendra Sharma,

    1. Department of Pediatrics and Pathology, Brown University, Providence, RI, USA
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  • Nazeeh N. Hanna

    1. Division of Neonatology, Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA
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Myriam A.J. Mondestin-Sorrentino, MD, Jersey Shore Perinatal Institute, Medical Arts Building, Suite 203, 1944 State Route 33, Neptune, NJ 07753, USA.
E-mail: mondesmy@umdnj.edu

Abstract

Problem

Data regarding cervical interleukin 18 (IL-8) and IL-10 concentrations during pregnancy is limited.

Method of study

This was a cross sectional study of healthy pregnant women. Specimens were collected from the cervical os secretions. IL-8 and IL-10 levels were measured by using enzyme-linked immunosorbent assay. Median (range) cytokine concentrations were derived for each trimester and compared across trimesters. The relationship between gestational age and cytokine levels was assessed by regression analysis. The mean of the ratios of IL-8 to IL-10 was compared in each trimester using anova.

Results

The median (range) IL-8 concentrations in cervical secretions were in pg/mL: 1562 (1210–4100), 2460 (1047–4688), 3660 (1451–4748) (P < 0.0021); the median (range) IL-10 concentrations in cervical secretions were in pg/mL: 38.3 (6.8–227.9), 10.9 (0–263.3), 9.5 (0–35.6); the mean IL10/IL-8 × 100 (+/− standard deviation) concentrations were: 3.33 ± 0.65, 1.47 ± 0.41, 0.38 ± 0.52 (P = 0.0035) during the first, second and third trimesters, respectively.

Conclusion

The patterns of cervical IL-8 concentration is inversely related to gestational age, and the ratio of IL-10/IL-8 decreases with advancing gestation.

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