Duration of Allergic Susceptibility in Maternal Transmission of Asthma Risk
Article first published online: 11 JUL 2007
American Journal of Reproductive Immunology
Volume 58, Issue 2, pages 120–128, August 2007
How to Cite
Fedulov, A. V., Leme, A. S. and Kobzik, L. (2007), Duration of Allergic Susceptibility in Maternal Transmission of Asthma Risk. American Journal of Reproductive Immunology, 58: 120–128. doi: 10.1111/j.1600-0897.2007.00496.x
- Issue published online: 11 JUL 2007
- Article first published online: 11 JUL 2007
- Submitted February 21, 2007; accepted March 26, 2007.
- maternal asthma;
Asthma has its origins in early-life. Maternal, not paternal asthma is an important risk factor, but the mechanisms and the duration of the maternal effect are unknown.
Method of Study
Offspring of asthmatic and normal mice were sensitized with ovalbumin (OVA) at 1, 3, 6 and 10 weeks of age, challenged with aerosolized OVA 2 weeks later and tested for airway hyperresponsiveness (AHR) and allergic airway inflammation (AI).
Offspring of asthmatic, but not normal, mothers showed AHR and AI after OVA sensitization at week 1. Similarly increased susceptibility to OVA was observed when sensitized at 3 or 6 weeks, although the magnitude diminished. Offspring sensitized at 10 and challenged at 12 weeks showed some AI but no AHR.
In offspring from asthmatic mothers increased allergic susceptibility persisted through the young adulthood, albeit with gradual decline, which suggests a long-lived but reversible skewing of the developing immune system.