Tolerance Signaling Molecules and Pregnancy: IDO, Galectins, and the Renaissance of Regulatory T Cells
Article first published online: 2 AUG 2007
American Journal of Reproductive Immunology
Volume 58, Issue 3, pages 238–254, September 2007
How to Cite
Terness, P., Kallikourdis, M., Betz, A. G., Rabinovich, G. A., Saito, S. and Clark, D. A. (2007), Tolerance Signaling Molecules and Pregnancy: IDO, Galectins, and the Renaissance of Regulatory T Cells. American Journal of Reproductive Immunology, 58: 238–254. doi: 10.1111/j.1600-0897.2007.00510.x
- Issue published online: 2 AUG 2007
- Article first published online: 2 AUG 2007
- Submitted April 6, 2007; accepted June 4, 2007.
- pregnancy immunology;
- Treg cells
Problem Is the concept of maternal tolerance preventing rejection of the semi-allogeneic ‘fetal allograft’ still valid?
Method of study Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1.
Results and Conclusion A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.