These authors contributed equally to this study.
Female Sex Steroid Hormones Modify Some Regulatory Properties of Monocyte-Derived Dendritic Cells
Version of Record online: 7 OCT 2007
American Journal of Reproductive Immunology
Volume 58, Issue 5, pages 425–433, November 2007
How to Cite
Kyurkchiev, D., Ivanova-Todorova, E., Hayrabedyan, S., Altankova, I. and Kyurkchiev, S. (2007), Female Sex Steroid Hormones Modify Some Regulatory Properties of Monocyte-Derived Dendritic Cells. American Journal of Reproductive Immunology, 58: 425–433. doi: 10.1111/j.1600-0897.2007.00526.x
- Issue online: 7 OCT 2007
- Version of Record online: 7 OCT 2007
- Submitted May 14, 2007; accepted August 8, 2007.
- dendritic cells;
Monocyte-derived dendritic cells (mDCs) are present in human decidua during the first month of pregnancy where they experience the effect of the increased concentration of progesterone (Pg) and estradiol (Estr). The aim of our study was to assess the effect of these reproductive hormones on the immunomodulatory role of mDCs.
Methods of study
The mDCs cultured in vitro in the presence of sex steroid hormones and characterized for their apoptosis and secretion of cytokines by flow cytometry, enzyme linked immunosorbent assay and proteome profiler kit.
Female sex steroid hormones enhance the life cycle of mDCs, thus increasing the maturation and apoptosis, they also increase the production of interleukin (IL)-10 and IL-27 but only Pg increases the production of IL-13 and down regulates the secretion of IL-23.
The Pg and Estr participate in the regulation of the immune response during pregnancy by influencing apoptosis and the cytokine profile of the mDCs.