Association of Killer Cell Immunoglobulin-like Receptor Genotypes with Susceptibility to Endometriosis
Version of Record online: 23 OCT 2007
American Journal of Reproductive Immunology
Volume 58, Issue 6, pages 481–486, December 2007
How to Cite
Kitawaki, J., Xu, B., Ishihara, H., Fukui, M., Hasegawa, G., Nakamura, N., Mizuno, S., Ohta, M., Obayashi, H. and Honjo, H. (2007), Association of Killer Cell Immunoglobulin-like Receptor Genotypes with Susceptibility to Endometriosis. American Journal of Reproductive Immunology, 58: 481–486. doi: 10.1111/j.1600-0897.2007.00533.x
- Issue online: 9 NOV 2007
- Version of Record online: 23 OCT 2007
- Submitted May 31, 2007; accepted August 14, 2007.
- genetic factor;
- human leukocyte antigen;
- killer cell immunoglobulin-like receptor;
- polymerase chain reaction sequence-specific primer
Problem Endometriosis is an immune-related chronic inflammatory disease with a polygenic predisposition. The aim of this study was to investigate whether polymorphisms in killer cell immunoglobulin-like receptors (KIRs) is responsible, in part, for genetic susceptibility to endometriosis.
Method of study The KIRs genotype was determined in 186 patients with endometriosis and 165 control women using polymerase chain reaction with sequence-specific primers.
Results The frequency of KIR3DS1 was significantly decreased in patients compared with controls (32%versus 44%, P = 0.028). KIR data were analyzed using a model comprised of three large groups, in which a gradient of activation/inhibitory potential derived from the combination of KIR and human leukocyte antigen (HLA) ligand genes was taken into account. The frequency of inhibitory KIRs/HLA-class I combination genotypes was significantly higher in patients than in controls (χ2 = 6.010, 2 df, P = 0.0496).
Conclusion Our results suggest that polymorphism in KIRs may be associated with susceptibility for endometriosis.