ORIGINAL ARTICLE: Circulating Antibodies to a Conserved Epitope of the Chlamydia Trachomatis 60-kDa Heat Shock Protein is Associated with Decreased Spontaneous Fertility Rate in Ectopic Pregnant Women Treated by Salpingectomy
Article first published online: 24 OCT 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
American Journal of Reproductive Immunology
Volume 59, Issue 2, pages 99–104, February 2008
How to Cite
Sziller, I., Fedorcsák, P., Csapó, Z., Szirmai, K., Linhares, I. M., Papp, Z. and Witkin, S. S. (2008), ORIGINAL ARTICLE: Circulating Antibodies to a Conserved Epitope of the Chlamydia Trachomatis 60-kDa Heat Shock Protein is Associated with Decreased Spontaneous Fertility Rate in Ectopic Pregnant Women Treated by Salpingectomy. American Journal of Reproductive Immunology, 59: 99–104. doi: 10.1111/j.1600-0897.2007.00553.x
- Issue published online: 24 OCT 2008
- Article first published online: 24 OCT 2008
- Submitted May 20, 2007; accepted October 22, 2007.
- Chlamydia trachomatis;
- conserved epitopes;
- ectopic pregnancy;
- 60-kDa heat shock protein;
Problem This prospective study was aimed to evaluate whether non-invasive clinical and serologic parameters of tubal disease are predictive for subsequent spontaneous conception and pregnancy outcome after first episode of ectopic pregnancy (EP).
Method of study Overall, 144 women aged <35 years were enrolled. Outcome of subsequent spontaneous conception was analyzed after 3 years and compared with clinical parameters and antibody responses to Chlamydia trachomatis and epitopes of the 60-kDa chlamydial heat shock protein (CHSP-60).
Results Antibody response to a conserved epitope of CHSP-60 (amino acids, aa 260–277) was independently correlated with both decreased spontaneous conception and term delivery rates (adjusted odds ratios, OR: 3.6 and 5.4, respectively).
Conclusion Presence of circulating antibodies to a conserved epitope of the CHSP-60 is associated with a lower spontaneous conception rate, and increased likelihood of adverse pregnancy outcome in women treated by salpingectomy for first episode of EP.