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ORIGINAL ARTICLE: Interleukin 6 –174 G/C Promoter Polymorphism and Pregnancy Complications: Results of a Prospective Cohort Study in 1626 Pregnant Women


Felix Stonek, MD, Department of Obstetrics and Gynecology, Danube Hospital Vienna, Langobardenstrasse 122, A-1220 Vienna, Austria.


Problem  To investigate the frequency of the interleukin-6 (IL-6) −174 G/C single nucleotide polymorphism (SNP) in women with intrauterine fetal death (IUFD), pre-eclampsia (PE), preterm delivery (PD), and small for gestational age (SGA) infants.

Method of study In a prospective cohort study, DNA from 1626 consecutive pregnant women was analyzed for IL-6 −174 G/C. Women who developed at least one of the predefined pregnancy complications were used as cases and compared with women without pregnancy complications.

Results Of 1626 women, 259 (15.9%) developed at least one pregnancy complication. IL-6 −174 G/C allele frequencies and genotype distributions were not significantly different between cases and controls. Similarly, no statistically significant difference in IL-6 −174 G/C genotype distribution in women with IUFD, PE, PD <34 weeks, PD >34 weeks and SGA infants <10th percentile was observed.

Conclusion IL-6 −174 G/C is not a genetic marker for identifying women at increased risk of common pregnancy complications.