Problem Is it possible to deliver therapeutic agents to testis through specific targeting?
Method of study Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase-C4 (LDH-C4), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo.
Results It is observed that LDHC4-immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo.
Conclusion Specific targeting through LDH-C4 appears to be a feasible strategy for delivering therapeutic as well as anti-spermatogenic agents to testis.