ORIGINAL ARTICLE: Testis Specific Lactate Dehydrogenase as Target for Immunoliposomes


R.C. Dutta Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL 60208, USA.
E-mail: ranjna_dutta@rediffmail.com


Problem  Is it possible to deliver therapeutic agents to testis through specific targeting?

Method of study  Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase-C4 (LDH-C4), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo.

Results  It is observed that LDHC4-immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo.

Conclusion  Specific targeting through LDH-C4 appears to be a feasible strategy for delivering therapeutic as well as anti-spermatogenic agents to testis.