ORIGINAL ARTICLE: Immune Status, Psychosocial Distress and Reduced Quality of Life in Infertile Patients with Endometriosis

Authors

  • Friederike Siedentopf,

    1. Department of Obstetrics and Gynecology, DRK-Kliniken Westend, Berlin, Germany
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    • *

      Both authors contributed equally to this study.

  • Nadja Tariverdian,

    1. Division of Psycho-Neuro-Immunology, Department of Internal Medicine/Dermatology, Charité– Universitätsmedizin Berlin, Berlin, Germany
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    • *

      Both authors contributed equally to this study.

  • Mirjam Rücke,

    1. Division of Psycho-Neuro-Immunology, Department of Internal Medicine/Dermatology, Charité– Universitätsmedizin Berlin, Berlin, Germany
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  • Heribert Kentenich,

    1. Department of Obstetrics and Gynecology, DRK-Kliniken Westend, Berlin, Germany
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  • Petra C. Arck

    1. Division of Psycho-Neuro-Immunology, Department of Internal Medicine/Dermatology, Charité– Universitätsmedizin Berlin, Berlin, Germany
    2. Department of Medicine, Brain Body Institute, McMaster University Hamilton, Hamilton, ON, Canada
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Friederike Siedentopf, Department of Obstetrics and Gynecology, DRK-Kliniken Westend, Spandauer Damm 130, D-14050 Berlin, Germany.
E-mail: f.siedentopf@drk-kliniken-westend.de

Abstract

Problem  The aim of the study was to identify if (i) psychosocial factors differ in endometriosis; (ii) related psychosocial aspects alter immune markers of depression/sickness behaviour; and (iii) serum immune marker may be indicative for endometriosis.

Method of study  We enrolled 103 women in a case–control study. Psychosocial data were obtained, serum levels of interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, interferon (IFN)-γ, TNF-α, IFN-α and soluble intercellular adhesion molecule-1 (sICAM-1) were analysed.

Results Among 69 eligible patients, endometriosis was diagnosed in 38 women. Patients with endometriosis reported reduced quality of life, increased stress perception/depressive symptoms; the Th1/Th2 ratio was in favour of Th1, accompanied by the increased levels of IFN-α. sICAM-1 levels were unaffected. No correlation could be confirmed between psychosocial and immune markers.

Conclusion  Women with endometriosis may benefit from strategies contributing to reduction of stress and development of coping mechanisms, thus helping to break the vicious circle of inflammation, sickness behaviour and depression.

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