ORIGINAL ARTICLE: Selective Downregulation of Phosphoinositide 3-Kinase alpha in Leukocytes During Pregnancy
Version of Record online: 11 JAN 2009
© 2009 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 61, Issue 2, pages 130–135, February 2009
How to Cite
Rohrbach, A., Rubio, I., Bulgay-Moerschel, M., Koenig, C., Poehlmann, T. G., Markert, U. R. and Gruen, M. (2009), ORIGINAL ARTICLE: Selective Downregulation of Phosphoinositide 3-Kinase alpha in Leukocytes During Pregnancy. American Journal of Reproductive Immunology, 61: 130–135. doi: 10.1111/j.1600-0897.2008.00672.x
- Issue online: 11 JAN 2009
- Version of Record online: 11 JAN 2009
- Submitted August 26, 2008; accepted November 11, 2008.
- maternal-fetal tolerance;
- phosphoinositide 3-kinase
Problem During pregnancy, it is crucially important that the mother’s immune system tolerates the developing embryo. Although a number of mechanisms of immunological tolerance have been described, little is known about intracellular signaling events, causing a decrease in the mother’s leukocyte activity.
Method of study We investigated the expression and activity of phosphoinositide 3-kinases (PI3K) in maternal blood cells of healthy volunteers by Reverse Transcription PCR and Western blotting.
Results Our data reveal a selective downregulation of the p110α catalytic isoform. This correlated with a slight decrease in PI3K activity as judged by the levels of phosphorylated Akt.
Conclusion As PI3K are involved in signal transduction of various leukocyte receptors, this downregulation may comprise a means of holding immune functions at bay.