SHORT COMMUNICATION: Interleukin-17 Increased Progesterone Secretion by JEG-3 Human Choriocarcinoma Cells
Article first published online: 2 MAR 2009
© 2009 The Authors. Journal compilation © 2009 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 61, Issue 4, pages 261–264, April 2009
How to Cite
Pongcharoen, S. and Supalap, K. (2009), SHORT COMMUNICATION: Interleukin-17 Increased Progesterone Secretion by JEG-3 Human Choriocarcinoma Cells. American Journal of Reproductive Immunology, 61: 261–264. doi: 10.1111/j.1600-0897.2009.00693.x
- Issue published online: 2 MAR 2009
- Article first published online: 2 MAR 2009
- Submitted December 10, 2008; accepted January 30, 2009.
- Human chorionic gonadotropin;
- JEG-3 human choriocarcinoma cell line;
Problem JEG-3 choriocarcinoma cell line has previously been reported to express a receptor for interleukin (IL)-17. The involvement of IL-17 in the production of progesterone and human chorionic gonadotropin by placental trophoblast has not been investigated.
Method of study The present study investigated the in vitro effect of IL-17 on progesterone and human chorionic gonadotropin (hCG) secretion by JEG-3 cells. Both hormones were quantified using enzyme-linked immunosorbent assays.
Results The results showed that IL-17 significantly increased progesterone secretion at 6 (P < 0.001) and 24 (P < 0.01) hr, while this cytokine had no effect on hCG secretion.
Conclusion Interleukin-17 may regulate the function of JEG-3 cells through increased progesterone secretion.