SEARCH

SEARCH BY CITATION

Keywords:

  • Cell migration;
  • chemokines;
  • Chlamydia;
  • lymphocytes;
  • murine

Problem Chlamydia trachomatis causes STI and reproductive dysfunction worldwide which is not preventable with antibiotics. Identifying a population of endocervical T cells to target in vaccine development would enhance efficacy.

Method of study  Trafficking of murine CD4+ lymphocytes to Chlamydia muridarum infected genital tract (GT) tissue in vivo was measured using adoptive transfer studies of fluorescent CD4+ T cells from integrin β7−/− mice or mice which lack E-selectin on endothelial cells.

Results  Murine in vivo migration studies showed that lack of α4β7 or E-selectin significantly reduced trafficking of CD4 T cells to the GT of mice infected with C. muridarum.

Conclusion  CD4+ T cells use at least two different adhesive mechanisms involving an integrin of the mucosal homing pathway and selectin pathway to accumulate in the GT during Cmuridarum infection.