ORIGINAL ARTICLE: Two Different Homing Pathways Involving Integrin β7 and E-selectin Significantly Influence Trafficking of CD4 Cells to the Genital Tract Following Chlamydia muridarum Infection
Article first published online: 22 APR 2009
© 2009 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 61, Issue 6, pages 438–445, June 2009
How to Cite
Kelly, K. A., Chan, A. M., Butch, A. and Darville, T. (2009), ORIGINAL ARTICLE: Two Different Homing Pathways Involving Integrin β7 and E-selectin Significantly Influence Trafficking of CD4 Cells to the Genital Tract Following Chlamydia muridarum Infection. American Journal of Reproductive Immunology, 61: 438–445. doi: 10.1111/j.1600-0897.2009.00704.x
- Issue published online: 6 MAY 2009
- Article first published online: 22 APR 2009
- Submitted December 30, 2008;accepted March 4, 2009.
- Cell migration;
Problem Chlamydia trachomatis causes STI and reproductive dysfunction worldwide which is not preventable with antibiotics. Identifying a population of endocervical T cells to target in vaccine development would enhance efficacy.
Method of study Trafficking of murine CD4+ lymphocytes to Chlamydia muridarum infected genital tract (GT) tissue in vivo was measured using adoptive transfer studies of fluorescent CD4+ T cells from integrin β7−/− mice or mice which lack E-selectin on endothelial cells.
Results Murine in vivo migration studies showed that lack of α4β7 or E-selectin significantly reduced trafficking of CD4 T cells to the GT of mice infected with C. muridarum.
Conclusion CD4+ T cells use at least two different adhesive mechanisms involving an integrin of the mucosal homing pathway and selectin pathway to accumulate in the GT during C. muridarum infection.