These authors have contributed equally as the first authors.
ORIGINAL ARTICLE: HLA-G Expression Is Up-Regulated by Progesterone in Mesenchymal Stem Cells
Article first published online: 9 JUN 2009
© 2009 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 62, Issue 1, pages 25–33, July 2009
How to Cite
Ivanova-Todorova, E., Mourdjeva, M., Kyurkchiev, D., Bochev, I., Stoyanova, E., Dimitrov, R., Timeva, T., Yunakova, M., Bukarev, D., Shterev, A., Tivchev, P. and Kyurkchiev, S. (2009), ORIGINAL ARTICLE: HLA-G Expression Is Up-Regulated by Progesterone in Mesenchymal Stem Cells. American Journal of Reproductive Immunology, 62: 25–33. doi: 10.1111/j.1600-0897.2009.00707.x
- Issue published online: 9 JUN 2009
- Article first published online: 9 JUN 2009
- Submitted February 24, 2009; accepted April 13, 2009.
- immune response;
- mesenchymal stem cells;
Problem Maternal immune response to fetal tissues is modified in such way that it favors the development of pregnancy. Human leukocyte antigen (HLA)-G, progesterone and mesenchymal stem cells (MSCs) have been identified as potent immunomodulatory agents in different experimental systems and the interactions between these three factors are studies in this paper.
Method of study Human MSCs are isolated from human adipose tissue, bone marrow and decidua are cultured in the presence of progesterone and the expression of HLA-G is followed-up at protein and mRNA levels.
Results The MSCs cultured in the presence of progesterone express increased levels of both cell surface and cytoplasmic HLA-G when compared with the control MSCs.
Conclusion Progesterone up-regulates the expression by MSCs of HLA-G which is a major player in maintenance of the immune balance between the mother and the fetus. MSCs are newly detected targets of progesterone with well documented immunomodulatory activity.