SHORT COMMUNICATION: Gender Ratio Distortion in Abortuses and Live Births From Patients with Recurrent Spontaneous Abortion
Version of Record online: 11 AUG 2009
© 2009 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 62, Issue 3, pages 125–127, September 2009
How to Cite
Kano, T., Mori, T. and Kimura, A. (2009), SHORT COMMUNICATION: Gender Ratio Distortion in Abortuses and Live Births From Patients with Recurrent Spontaneous Abortion. American Journal of Reproductive Immunology, 62: 125–127. doi: 10.1111/j.1600-0897.2009.00721.x
- Issue online: 11 AUG 2009
- Version of Record online: 11 AUG 2009
- Submitted May 19, 2009; accepted June 15, 2009.
- chromosomal abnormality;
Problem Gender ratio of live birth in humans is approximately 1.05 and males are born a slightly more, while gender ratio of fertilization should be 1.00, suggesting that female fetus might be more sensitive to abortion than male fetus during pregnancy.
Method of study We examined karyotype of abortuses from patients with recurrent spontaneous abortion (RSA), who had at least one live birth before or after the treatment of RSA.
Results Chromosomal abnormality was not frequent (14.6%) in the abortuses from the RSA patients. Among abortuses without chromosomal abnormality, male karyotype was rare (9.2%), and this gender ratio distortion was more prominent in RSA cases not carrying autoantibodies (3.5%) than that in the RSA cases carrying autoantibodies (26.3%), with statistical significance (P = 0.009).
Conclusion These observations suggested that the aborted fetuses from RSA of unknown etiology, i.e. no chromosomal abnormality and no autoantibody, were preferentially female.