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ORIGINAL ARTICLE: Women with Pre-Eclampsia Have an Altered NKG2A and NKG2C Receptor Expression on Peripheral Blood Natural Killer Cells

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This article is corrected by:

  1. Errata: ERRATUM: Women with Pre-Eclampsia have an Altered NKG2A and NKG2C Receptor Expression on Peripheral Blood Natural Killer Cells Volume 62, Issue 5, 348, Article first published online: 7 October 2009

Eva Sverremark-Ekström, Department of Immunology, Stockholm University, Svante Arrheniusväg 16-18, 106 91 Stockholm, Sweden. E-mail: eva.sverremark@imun.su.se

Abstract

Problem  Preeclampsia, a pregnancy disorder, is associated with exaggerated inflammation and increased serum monokines. Uterine natural killer (NK) cells are implicated in preeclampsia pathology, but little is known regarding peripheral NK cells in the disease.

Method of Study  We examined blood NK cells at delivery in women with preeclampsia, in healthy pregnant women and in healthy non-pregnant blood donors as a reference.

Results  Although the percentages of both NKG2A- and NKG2C-positive NK cells were normal in preeclamptic women, the levels of NKG2A and NKG2C on NK cells were significantly up-regulated in these women. In vitro stimulation of PBMCs from healthy pregnant women and blood donors with monokines resulted in increased percentage of NKG2A+ NK cells and increased NKG2A levels, while levels of NKG2C were decreased.

Conclusions  Our results suggest that the peripheral NK-cell pool is skewed in preeclampsia and possibly under the influence of monokines like interleukin (IL)-15 and IL-12.

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