ORIGINAL ARTICLE: Cytokine Array Comparisons of Plasma from Cycling Fertile Women on Cycle Day 5 and Ovulation

  1. Kota Hatta1,†,
  2. Michael J. Bilinski2,†,
  3. J. Kimberly Haladyn3,†,
  4. Jessica J. Roy2,†,
  5. Julie Horrocks3,
  6. Marianne J. Van Den Heuvel4,
  7. Victor K. Han5,
  8. B. Anne Croy2

Article first published online: 11 AUG 2009

DOI: 10.1111/j.1600-0897.2009.00725.x

Issue

American Journal of Reproductive Immunology

American Journal of Reproductive Immunology

Volume 62, Issue 3, pages 158–164, September 2009

Additional Information

How to Cite

Hatta, K., Bilinski, M. J., Haladyn, J. K., Roy, J. J., Horrocks, J., Van Den Heuvel, M. J., Han, V. K. and Croy, B. A. (2009), ORIGINAL ARTICLE: Cytokine Array Comparisons of Plasma from Cycling Fertile Women on Cycle Day 5 and Ovulation. American Journal of Reproductive Immunology, 62: 158–164. doi: 10.1111/j.1600-0897.2009.00725.x

Author Information

  1. 1

    Department of Microbiology and Immunology, Queen’s University, Kingston, ON, Canada

  2. 2

    Department of Anatomy and Cell Biology, Queen’s University, Kingston, ON, Canada

  3. 3

    Department of Mathematics and Statistics, University of Guelph, Guelph, ON, Canada

  4. 4

    Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada

  5. 5

    Department of Pediatrics, Children’s Health Research Institute, University of Western Ontario, London, ON, Canada

  1. †

    These authors contributed equally.

*Kota Hatta, Queen’s University, Department of Microbiology and Immunology, Botterell Hall Room 813, 18 Stuart Street, Kingston, ON K7L 3N6, Canada. E-mail: 7kh17@queensu.ca

  • †

    These authors contributed equally.

Publication History

  1. Issue published online: 11 AUG 2009
  2. Article first published online: 11 AUG 2009
  3. Submitted March 21, 2009; accepted June 29, 2009.

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Keywords:

  • Cytokine array;
  • menstrual cycle;
  • plasma

Problem  To identify plasma immuno-regulatory molecules up or down regulated between the follicular phase and ovulation of the human menstrual cycle.

Method of study  RayBio® cytokine arrays were used to screen 174 immuno-regulatory molecules in plasma collected during the follicular phase at menstrual cycle day 5 and at ovulation from five healthy, non-smoking, fertile women of reproductive age not using hormonal contraception.

Results  A total of 23 differentially expressed molecules were found: 10 molecules were differentially up-regulated and 13 down-regulated at ovulation compared with that at the follicular phase (α = 0.05, false discovery rate of 0.45).

Conclusion  Circulating immuno-regulatory molecules fluctuate over the menstrual cycle in healthy women. The combination of differentially expressed molecules suggests roles in cyclical regulation of angiogenesis and immune cell trafficking.

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