ORIGINAL ARTICLE: Plasma C3a-des-Arg Levels in Women with and without Endometriosis
Article first published online: 11 AUG 2009
© 2009 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 62, Issue 3, pages 187–195, September 2009
How to Cite
Fassbender, A., D’Hooghe, T., Mihalyi, A., Kyama, C., Simsa, P. and Lessey, B. A. (2009), ORIGINAL ARTICLE: Plasma C3a-des-Arg Levels in Women with and without Endometriosis. American Journal of Reproductive Immunology, 62: 187–195. doi: 10.1111/j.1600-0897.2009.00728.x
- Issue published online: 11 AUG 2009
- Article first published online: 11 AUG 2009
- Submitted December 19, 2008; accepted July 2, 2009.
- non-invasive diagnostic test
Problem The lack of a reliable method for early non-invasive detection of endometriosis often results in delayed diagnosis. The aim of this study was to test the hypothesis that the plasma concentration of complement factor C3a (anaphylatoxin) can be used as a non-invasive test in the diagnosis of endometriosis.
Method of study The C3a concentration was analyzed using ELISA in 160 patients with (n = 109) or without (n = 51) endometriosis during menstruation (n = 49), follicular phase (n = 55), and luteal (n = 56) phase.
Results Plasma C3a concentration was comparable between patients with [102 (27–2213) ng/mL] and without [105 (32–2340) ng/mL] (P = 0.84) endometriosis, also when assessed separately during menstruation, follicular phase, and luteal phase.
Conclusion We found no difference in C3a levels between women with and without endometriosis and did not confirm our hypothesis that plasma C3a levels can be used as diagnostic test for endometriosis.