ORIGINAL ARTICLE: Serum IL-6 Level May Have Role in the Pathophysiology of Unexplained Infertility
Article first published online: 24 AUG 2009
© 2009 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 62, Issue 4, pages 261–267, October 2009
How to Cite
Demir, B., Guven, S., Guvendag Guven, E. S., Atamer, Y. and Gul, T. (2009), ORIGINAL ARTICLE: Serum IL-6 Level May Have Role in the Pathophysiology of Unexplained Infertility. American Journal of Reproductive Immunology, 62: 261–267. doi: 10.1111/j.1600-0897.2009.00734.x
- Issue published online: 11 SEP 2009
- Article first published online: 24 AUG 2009
- Submitted June 21, 2009; accepted July 21, 2009.
- serum level;
- unexplained infertility
Problem The aim of this study was to compare the serum levels of interleukin (IL)-6 of women with unexplained infertility with fertile subjects.
Method of study Serum IL-6, and tumor necrosis factor-α (TNF-α) levels of 45 infertile and 44 fertile women on day 3 of menstrual cycle were assessed and compared for this prospective controlled study.
Results The mean serum IL-6 level was significantly higher in women with unexplained infertility, compared with fertile women (5.71 ± 1.81 and 4.31 ± 1.79, P < 0.001, Student’s t-test). There was no significant difference in TNF-α level among the groups.
Conclusion Significant difference in serum IL-6 levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.