REVIEW ARTICLE: Toll-Like Receptor Signaling and Pre-Eclampsia
Version of Record online: 14 DEC 2009
© 2009 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 63, Issue 1, pages 7–16, January 2010
How to Cite
Xie, F., Turvey, S. E., Williams, M. A., Mor, G. and Von Dadelszen, P. (2010), REVIEW ARTICLE: Toll-Like Receptor Signaling and Pre-Eclampsia. American Journal of Reproductive Immunology, 63: 7–16. doi: 10.1111/j.1600-0897.2009.00745.x
- Issue online: 14 DEC 2009
- Version of Record online: 14 DEC 2009
- Submitted June 24, 2009; accepted August 17, 2009.
- Toll-like receptors signaling
Systemic inflammation and abnormal/poor placentation represent hallmarks of pre-eclampsia. Accumulating evidence suggests that infectious agents might increase the risk of pre-eclampsia; the innate immune defense mechanisms may interact with pro-inflammatory pathways, and contribute to the development of pre-eclampsia. The evidence for this has been supported by indirect epidemiologic and clinical studies, as well as by some direct support from experimental studies. Recent data directly implicate signaling by Toll-like receptors in the pathogenesis of pre-eclampsia, and establish a crucial link between pre-eclampsia and defense against both foreign pathogens and endogenously generated inflammatory ligands. Here, we review the rapid progress in this field, which has improved our understanding of the interplay between pathogen invasion, innate immune defense mechanisms, and pre-eclampsia.