Presented at the 29th Annual Meeting of the American Society of Reproductive Immunology, 2009.
REVIEW ARTICLE: What the Sperm Says and the Egg Hears – A Tale of Two Proteins and More
Version of Record online: 6 NOV 2009
© 2009 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 62, Issue 6, pages 357–364, December 2009
How to Cite
Bronson, R. (2009), REVIEW ARTICLE: What the Sperm Says and the Egg Hears – A Tale of Two Proteins and More. American Journal of Reproductive Immunology, 62: 357–364. doi: 10.1111/j.1600-0897.2009.00758.x
- Issue online: 6 NOV 2009
- Version of Record online: 6 NOV 2009
- Submitted August 11, 2009; accepted September 1, 2009.
While considerable information exists regarding the early interactions of spermatozoon and egg that lead to successful fertilization, the molecular biology of events that result in the incorporation of the spermatozoon within the cortical ooplasm is largely undefined. There is circumstantial evidence suggesting that this process involves the interactions of specific oolemmal receptors and their ligands on sperm that bear similarities to mechanisms used in phagocytosis by macrophages. We have postulated that the egg may act as a ‘non-professional phagocyte’ during its association with the spermatozoon. This review surveys those events, provides an historical context, and creates a paradigm for further investigation.