ORIGINAL ARTICLE: Imbalance of T-cell Transcription Factors Contributes to the Th1 Type Immunity Predominant in Pre-eclampsia
Article first published online: 12 NOV 2009
© 2009 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 63, Issue 1, pages 38–45, January 2010
How to Cite
Jianjun, Z., Yali, H., Zhiqun, W., Mingming, Z. and Xia, Z. (2010), ORIGINAL ARTICLE: Imbalance of T-cell Transcription Factors Contributes to the Th1 Type Immunity Predominant in Pre-eclampsia. American Journal of Reproductive Immunology, 63: 38–45. doi: 10.1111/j.1600-0897.2009.00763.x
- Issue published online: 14 DEC 2009
- Article first published online: 12 NOV 2009
- Submitted July 18, 2009; accepted September 10, 2009.
- Forkhead box P3;
- T-bet Th1/Th2;
- transcription factor
Problem Extensive studies have demonstrated that Th1 type immunity is predominant in pre-eclampsia, but there is little concern with regard to the intracellular mechanisms behind this initial T-cell polarization. In this study, we investigated whether the imbalance of the T-cell transcription factors contributes to it.
Method of study A total of 15 pre-eclamptic patients and 15 healthy pregnant women were enrolled in this study. The expression levels of transcription factors for Th1 (T-bet), Th2 (GATA3), Th17 (RORc) and Treg (FOXP3) cells, together with the Th1/Th2 status, were simultaneously investigated in both peripheral blood mononuclear cells (PBMCs) and decidua.
Results The expression levels of FOXP3 mRNA were decreased in both PBMCs and decidua from pre-eclamptic patients compared with healthy pregnant women (P < 0.05), and T-bet mRNA and RORc mRNA were significantly increased (P < 0.05), while Th1/Th2 balance shifted toward the Th1 immunity. Furthermore, there was a negative correlation between FOXP3 mRNA and Th1 cells (P < 0.05), and the expression level of T-bet mRNA correlated strongly with Th1 cells (P < 0.05).
Conclusion Decreased expression of FOXP3 mRNA and increased expression of T-bet mRNA may contribute to Th1 type immunity predominant in pre-eclampsia.