SHORT COMMUNICATION: STAT3 Polymorphisms Linked with Idiopathic Recurrent Miscarriages


Wassim Y. Almawi, Department of Medical Biochemistry, College of Medicine & Medical Sciences, Arabian Gulf University, PO Box 22979, Manama, Bahrain.


Problem  We investigated the association of signal transducers and activators of transcription (STAT)3 gene variants with idiopathic recurrent miscarriage (RM).

Method of Study  A case–control study involving 189 RM patients and 244 control women was carried out. STAT3 (rs1053004 and rs1023023) genotyping was performed by allelic discrimination/real-time PCR method.

Results STAT3 rs1053004 C allele [OR (95% CI) = 1.60 (1.22–2.10)] and C/C genotype [OR (95% CI) = 3.42 (1.70–6.92)] were positively associated with RM. Two-locus (rs1053004/rs1053023) haplotype analysis revealed increased frequency of CG and CA haplotypes in RM patients, of which only CA haplotype (Pc = 0.020) remained positively associated with RM after applying the Bonferroni correction. This was confirmed by multivariate regression analysis (OR = 1.70; 95% CI = 1.17–2.46) after adjusting for a number of covariates.

Conclusion STAT3 rs1053004 variant is significantly associated with idiopathic RM. Replication studies on other racial groups and other STAT3 gene variants are warranted.