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ORIGINAL ARTICLE: No Association Between the GSTP1 Exon 5 Polymorphism and Susceptibility to Advanced Stage Endometriosis in the Korean Population

Authors

  • Myung Jae Jeon,

    1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea
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  • Young Min Choi,

    1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea
    2. The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea
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  • Min A Hong,

    1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea
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  • Gyoung Hoon Lee,

    1. The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea
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  • Seung Yup Ku,

    1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea
    2. The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea
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  • Seok Hyun Kim,

    1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea
    2. The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea
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  • Jung Gu Kim,

    1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea
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  • Shin Yong Moon

    1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea
    2. The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea
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Young Min Choi, Department of Obstetrics & Gynecology, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-ku, Seoul 110-744, South Korea.
E-mail: ymchoi@snu.ac.kr

Abstract

CitationJeon MJ, Choi YM, Hong MA, Lee GH, Ku SY, Kim SH, Kim JG, Moon SY. No Association between the GSTP1 exon 5 polymorphism and susceptibility to advanced stage endometriosis in the Korean population. Am J Reprod Immunol 2010; 63: 222–226

Problem  To investigate whether the glutathione-S-transferase P1 (GSTP1) exon 5 polymorphism is associated with susceptibility to advanced stage endometriosis in Korean women.

Method of study  Case–control study in a collective of 260 patients and 164 controls. Genotyping of the GSTP1 exon 5 polymorphism was performed by using real-time TaqMan PCR assay.

Results  The genotype distribution of the GSTP1 exon 5 polymorphism in the endometriosis group was not significantly different from that of the control group (AA/AG/GG rates were 64.2%/32.7%/3.1% and 65.2%/31.7%/3.0% for the endometriosis and control groups, respectively, = 0.977). Further subgroup analysis according to either stage or bilaterality of ovarian endometrioma also found no significant difference in the genotype distribution between any of the endometriosis subgroups and the control group.

Conclusion  These findings suggest that the GSTP1 exon 5 polymorphism is not a major determinant of the development of advanced stage endometriosis in the Korean population.

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