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OPINION: Some Severe Maternal Diseases Might be Caused by Fetal-Versus-Maternal Disease (FVMD)

Authors


Xingbo Zhao, Department of Obstetrics and Gynecology, Provincial Hospital affiliated to Shandong University, Jinan, China.
E-mail: zhaoxingboandu@yahoo.cn

Abstract

Citation Yan L, Zuo C, Wei D, Zhao X. Some severe maternal diseases might be caused by fetal-versus-maternal disease (FVMD). Am J Reprod Immunol 2010; 63: 189–192

Pregnancy-related disease is a common challenging clinical problem. From our review and clinical experience, we hypothesize that many severe pregnancy-related complications might be caused by a fetal-versus-maternal disease (FVMD), based on the fact that maternal disease is related to immunity and that fetal cells are present in maternal blood. Fetus is a semi-antigen and can be considered as a tumor or graft. The pathophysiology of FVMD must be complex. We speculate it to be a three-step process: impaired maternal immunological function, fetal T-cell activation and injury of target organs. More experiments and research will be needed to prove our hypothesis.

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