OPINION: Immunologic Abnormality of Intrahepatic Cholestasis of Pregnancy
Article first published online: 19 JAN 2010
© 2010 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 63, Issue 4, pages 267–273, April 2010
How to Cite
Yayi, H., Danqing, W., Shuyun, L. and Jicheng, L. (2010), OPINION: Immunologic Abnormality of Intrahepatic Cholestasis of Pregnancy. American Journal of Reproductive Immunology, 63: 267–273. doi: 10.1111/j.1600-0897.2009.00798.x
- Issue published online: 10 MAR 2010
- Article first published online: 19 JAN 2010
- Submitted October 14, 2009; accepted November 17, 2009.
Citation Yayi H, Danqing W, Shuyun L, Jicheng L. Immunologic Abnormality of Intrahepatic Cholestasis of Pregnancy. Am J Reprod Immunol 2010; 63: 267–273
Problem Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy risk because of the possibility of pre-term delivery and sudden intrauterine fetal death. Its pathogenesis is still under discussion.
Method of study The analysis of the recent findings on the complex immunologic events that occur in ICP were performed.
Results In ICP, an increase of type 1 cytokine (TNF-α, IFN-γ) associated with a decrease of type 2 cytokine (IL-4). The decreased production of the suppressor cytokine TGF-β2 may increase the type 1 cytokine. Fas appeared to be increased and FasL appeared to be decreased in syncytiotrophoblasts of ICP. The human leukocyte antigen gene (HLA-G, E) in extravillous trophoblasts of ICP were significantly decreased.
Conclusion Th1/Th2 cytokine balance and HLA play important roles in the tolerance and maintenance of pregnancy. ICP may be resulting from breach of the maternal fetal immune tolerance during pregnancy.