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ORIGINAL ARTICLE: Contribution of Interferon-γ Receptor 1 Gene Polymorphisms to Pre-Eclampsia in China


Hao Zhou, Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan 430022, China.


Citation Chen L-J, Gao H, Zhou H, Zou L, Zou P. Contribution of interferon-γ receptor 1 gene polymorphisms to pre-eclampsia in China. Am J Reprod Immunol 2010; 63: 331–338

Problem  As gene polymorphisms of cytokines receptors have been found to significantly influence cell responses to cytokines, the aim of this study was to test the hypothesis that IFN-γ receptor 1 (IFNGR1) gene polymorphisms may contribute to the pathogenesis of pre-eclampsia.

Method of study  One hundred and sixty-four pre-eclamptic patients (121 patients with mild pre-eclampsia and 43 patients with severe pre-eclampsia) and 171 controls were included. Polymorphisms of the IFNGR1 gene at positions −611, −270, +56 and +95 were genotyped with the matrix-assisted laser desorption/ionization time of flight mass spectrometry.

Results  This study showed a positive association between −56C/C genotype (OR = 1.7; 95% CI = 1.1–2.7) and pre-eclampsia. Although the genotype frequencies (except for −56C/C) of the two polymorphisms were comparable between cases and controls, higher frequency of the −611A/−56C haplotype (OR = 1.450; 95% CI = 1.070–1.966) was noticed in patients versus controls. All patients and controls were homozygous for the −270T/T and +95T/T genotypes. Specifically, the frequency of the −56C allele (OR = 1.838; 95% CI = 1.127–2.995) was higher among patients with severe pre-eclampsia.

Conclusion  The IFNGR1 gene polymorphisms may contribute to the pathogenesis of pre-eclampsia in our population.

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