ORIGINAL ARTICLE: Hyperresistinemia – a Novel Feature in Systemic Infection During Human Pregnancy
Article first published online: 18 FEB 2010
Published 2010. This article is a US Government work and is in the public domain in the USA
American Journal of Reproductive Immunology
Volume 63, Issue 5, pages 358–369, May 2010
How to Cite
Mazaki-Tovi, S., Vaisbuch, E., Romero, R., Kusanovic, J. P., Chaiworapongsa, T., Kim, S. K., Ogge, G., Yoon, B. H., Dong, Z., Gonzalez, J. M., Gervasi, M. T. and Hassan, S. S. (2010), ORIGINAL ARTICLE: Hyperresistinemia – a Novel Feature in Systemic Infection During Human Pregnancy. American Journal of Reproductive Immunology, 63: 358–369. doi: 10.1111/j.1600-0897.2010.00809.x
- Issue published online: 9 APR 2010
- Article first published online: 18 FEB 2010
- Submitted December 28, 2009; accepted January 8, 2010.
- Acute bacterial infection;
- body mass index;
- systemic inflammatory response syndrome;
- urinary tract infection
Citation Mazaki-Tovi S, Vaisbuch E, Romero R, Kusanovic JP, Chaiworapongsa T, Kim SK, Ogge G, Yoon BH, Dong Z, Gonzalez JM, Gervasi MT, Hassan SS. Hyperresistinemia – a novel feature in systemic infection during human pregnancy. Am J Reprod Immunol 2010
Problem Resistin, originally described as an adipokine, has emerged as a potent pro-inflammatory protein associated with both acute and chronic inflammation. Moreover, resistin has been proposed as a powerful marker of sepsis severity, as well as a predictor of survival of critically ill non-pregnant patients. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma resistin concentrations.
Methods of study This cross-sectional study included the following groups: (i) normal pregnant women (n = 85) and (ii) pregnant women with pyelonephritis (n = 40). Maternal plasma resistin concentrations were determined by ELISA. Non-parametric statistics was used for analyses.
Results (i) The median maternal plasma resistin concentration was higher in patients with pyelonephritis than in those with a normal pregnancy (P < 0.001); (ii) among patients with pyelonephritis, the median maternal resistin concentration did not differ significantly between those with and without a positive blood culture (P = 0.3); (iii) among patients with pyelonephritis who were diagnosed with systemic inflammatory response syndrome (SIRS), those who fulfilled ≥3 criteria for SIRS had a significantly higher median maternal plasma resistin concentration than those who met only two criteria; and (iv) maternal WBC count positively correlated with circulating resistin concentration (r = 0.47, P = 0.02).
Conclusion Hyperresistinemia is a feature of acute pyelonephritis during pregnancy. The results of this study support the role of resistin as an acute-phase protein in the presence of bacterial infection during pregnancy.