A.N. and M.I. contributed equally to the study.
Accumulation of IL-17-Positive Cells in Decidua of Inevitable Abortion Cases
Article first published online: 4 MAR 2010
© 2010 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 64, Issue 1, pages 4–11, July 2010
How to Cite
Nakashima, A., Ito, M., Shima, T., Bac, N. D., Hidaka, T. and Saito, S. (2010), Accumulation of IL-17-Positive Cells in Decidua of Inevitable Abortion Cases. American Journal of Reproductive Immunology, 64: 4–11. doi: 10.1111/j.1600-0897.2010.00812.x
- Issue published online: 7 JUN 2010
- Article first published online: 4 MAR 2010
- Submitted December 7, 2009; accepted January 13, 2010.
Citation Nakashima A, Ito M, Shima T, Bac ND, Hidaka T, Saito S. Accumulation of IL-17-positive cells in decidua of inevitable abortion cases. Am J Reprod Immunol 2010
Problem Th17 cells, a new subset of helper T cells, have been focused on as a producer pro-inflammatory cytokines. It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL-17-producing cells in human spontaneous abortion.
Method of study IL-17 expression was analyzed in decidual tissues among normal pregnancy, missed abortion, and inevitable abortion cases by immunohistochemistry and flow cytometry.
Results IL-17+ cells were accumulated in decidua and were detected in decidual CD4+ T cells and few decidual CD8+ T cells in spontaneous abortion cases. The number of decidual IL-17+ cells in inevitable abortion cases involving active genital bleeding was significantly higher than that in normal pregnancy cases (P < 0.05). On the other hand, there were no significant differences in the numbers of decidual IL-17+ cells between missed abortion cases and normal pregnancy subjects. Furthermore, the number of IL-17+ cells was positively correlated with the number of neutrophils in spontaneous abortion cases.
Conclusion IL-17+ cells might be involved in the induction of inflammation in the late stage of abortion, but not in the early stage of abortion.