REVIEW ARTICLE: The Contribution of Macrophages to Normal and Pathological Pregnancies
Article first published online: 16 FEB 2010
© 2010 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 63, Issue 6, pages 460–471, June 2010
How to Cite
Nagamatsu, T. and Schust, D. J. (2010), REVIEW ARTICLE: The Contribution of Macrophages to Normal and Pathological Pregnancies. American Journal of Reproductive Immunology, 63: 460–471. doi: 10.1111/j.1600-0897.2010.00813.x
- Issue published online: 10 MAY 2010
- Article first published online: 16 FEB 2010
- Submitted January 13, 2010; accepted January 14, 2010.
- cervical ripening;
- immune tolerance;
Citation Nagamatsu T, Schust DJ. The contribution of macrophages to normal and pathological pregnancies. Am J Reprod Immunol 2010
Macrophages represent one of the major leukocyte subsets in the uterine decidua. Owing to their remarkable phenotypic plasticity, decidual macrophages can participate in diverse activities during pregnancy. At baseline, decidual macrophages are characterized by an immunosuppressive phenotype and M2 polarization, supporting feto-maternal immune tolerance. In early pregnancy, macrophage-derived pro-angiogenic factors prompt vascular remodeling within the uterine wall to ensure appropriate utero-placental circulation. Upon invasion by pathogens, pattern recognition receptors on decidual macrophages help to alter the characteristics of these malleable cells toward an M1, inflammatory phenotype. Similar inflammatory characteristics are seen in those macrophages that accumulate in the lower segment of the uterus to drive cervical ripening. Disturbances in the tight control that balances macrophage function during pregnancy can trigger the development of pregnancy complications. Here, we discuss the physiologic role of uterine macrophages at different stages of pregnancy and describe their relevance in selected pregnancy disorders.