Is Apolipoprotien E codon 112 Polymorphisms Associated with Recurrent Pregnancy Loss?
Article first published online: 17 FEB 2010
© 2010 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 64, Issue 2, pages 87–92, August 2010
How to Cite
Ozornek, H., Ergin, E., Jeyendran, R. S., Ozay, A. T., Pillai, D. and Coulam, C. (2010), Is Apolipoprotien E codon 112 Polymorphisms Associated with Recurrent Pregnancy Loss?. American Journal of Reproductive Immunology, 64: 87–92. doi: 10.1111/j.1600-0897.2010.00814.x
- Issue published online: 6 JUL 2010
- Article first published online: 17 FEB 2010
- Submitted December 11, 2009; accepted January 15, 2010.
- Apo E4 codon 112C and 158C;
- Apolipoprotein E4;
- recurrent pregnancy loss
Citation Ozornek H, Ergin E, Jeyendran RS, Ozay AT, Pillai D, Coulam C. Is Apolipoprotien E codon 112 polymorphisms associated with recurrent pregnancy loss? Am J Reprod Immunol 2010; 64: 87–92
Problem To compare the prevalence of 112T>C point mutations among women experiencing RPL with fertile control women.
Method of Study Buccal swabs were obtained from 232 individuals: 136 with a history of ≥2 abortions, 37 with at least 2 live births and 59 with a history of deep vein thrombosis (DVT). DNA was extracted and PCR amplification of Apo E codons was performed.
Results The allelic frequency of a cytosine at position 112 was 11.4% (31/272) among patients experiencing RPL, compared with a frequency of 5.4% (4/74) among the fertile controls (P = 0.19) and 19.5% (23/118) among individuals with a history of DVT. However, significantly more E3/E4 and E4/E4 genotypes were seen among individuals experiencing RPL and DVT than fertile controls (P < 0.05).
Conclusion Apo E4 codon 112C point mutation is, by itself, not associated with an elevated risk of recurrent pregnancy loss, but rather codon 112C in association with codon 158C is a risk factor for RPL.