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  • 1
    Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M: Immunological self-tolerance maintained by activated T-cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various auto-immune diseases. J Immunol 1995; 155:11511164.
  • 2
    Kingsley CL, Karim M, Bushell AR, Wood K: CD25+CD4+ regulatory T cells prevent graft rejection: CTLA4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002; 168:10801086.
  • 3
    Hori S, Nomura T, Sakaguchi S: Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:10571061.
  • 4
    Fontenot JD, Rudensky AY: A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005; 6:331337.
  • 5
    Fontenot JD, Gavin MA, Rudensky AY: Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4:330336.
  • 6
    Sakaguchi S: Naturally Arising CD4+ Regulatory T Cells for Immunologic Self-Tolerance and Negative Control of Immune Responses. Annu Rev Immunol 2004; 22:531562.
  • 7
    Apostolou I, Sarukhan A, Klein L, Von Boehmer H: Origin of regulatory T cells with known specificity for antigen. Nat Immunol 2002; 3:756763.
  • 8
    Reichardt P, Dornbach B, Rong S, Beissert S, Gueler F, Loser K, Gunzer M: Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse. Blood 2007; 110:15191529.
  • 9
    Somerset DA, Zheng Y, Kilby MD, Sansom DM, Drayson MT: Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology 2004; 112:3843.
  • 10
    Mjösberg J, Svensson J, Johansson E, Hellström L, Casas R, Jenmalm MC, Boij R, Matthiesen L, Jönsson JI, Berg G, Ernerudh J: Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17beta-estradiol. J Immunol 2009; 183:759769.
  • 11
    Mjösberg J, Berg G, Ernerudh J, Ekerfelt C: CD4+ CD25+ regulatory T cells in human pregnancy: development of a Treg-MLC-ELISPOT suppression assay and indications of paternal specific Tregs. Immunology 2007; 120:456466.
  • 12
    Tilburgs T, Roelen DL, Van Der Mast BJ, De Groot-Swings GM, Kleijburg C, Scherjon SA, Claas FH: Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. J Immunol 2008; 180:57375745.
  • 13
    Jasper MJ, Tremellen KP, Robertson SA: Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Mol Hum Reprod 2006; 12:301308.
  • 14
    Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A, Saito S: Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod 2004; 10:347353.
  • 15
    Arruvito L, Billordo A, Capucchio M, Prada ME, Fainboim L: IL-6 trans-signaling and the frequency of CD4+FOXP3+ cells in women with reproductive failure. J Reprod Immunol 2009; 82:158165.
  • 16
    Mjösberg J, Berg G, Jenmalm MC, Ernerudh J: FOXP3+ Regulatory T Cells and T Helper 1, T Helper 2, and T Helper 17 Cells in Human Early Pregnancy Decidua. Biol Reprod 2009, DOI:10.1095/biolreprod.109.081208.
  • 17
    Sasaki Y, Darmochwal-Kolarz D, Suzuki D, Sakai M, Ito M, Shima T, Shiozaki A, Rolinski J, Saito S: Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsia. Clin Exp Immunol 2007; 149:139145.
  • 18
    Paeschke S, Chen F, Horn N, Fotopoulou C, Zambon-Bertoja A, Sollwedel A, Zenclussen ML, Casalis PA, Dudenhausen JW, Volk HD, Zenclussen AC: Pre-eclampsia is not associated with changes in the levels of regulatory T cells in peripheral blood. Am J Reprod Immunol 2005; 54:384389.
  • 19
    Santner-Nanan B, Peek MJ, Khanam R, Richarts L, Zhu E, Fazekas de St Groth B, Nanan R: Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. J Immunol 2009; 183:70237030.
  • 20
    Prins JR, Boelens HM, Heimweg J, Van der Heide S, Dubois AE, Van Oosterhout AJ, Erwich JJ: Preeclampsia is associated with lower percentages of regulatory T cells in maternal blood. Hypertens Pregnancy 2009; 28:300311.
  • 21
    Toldi G, Svec P, Vásárhelyi B, Mészáros G, Rigó J, Tulassay T, Treszl A: Decreased number of FoxP3+ regulatory T cells in preeclampsia. Acta Obstet Gynecol Scand 2008; 87:12291233.
  • 22
    Aluvihare VR, Kallikourdis M, Betz AG: Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 2004; 5:266271.
  • 23
    Zenclussen AC, Gerlof K, Zenclussen ML, Sollwedel A, Zambon Bertoja A, Ritter T, Kotsch K, Leber J, Volk HD: Abnormal T cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model. Am J Pathol 2005; 166:811822.
  • 24
    Thuere C, Zenclussen ML, Schumacher A, Langwisch S, Schulte-Wrede U, Teles A, Paeschke S, Volk HD, Zenclussen AC: Kinetics of regulatory T cells during murine pregnancy. Am J Reprod Immunol 2007; 58:514523.
  • 25
    Tai P, Wang J, Jin H, Song X, Yan J, Kang Y, Zhao L, An X, Du X, Chen X, Wang S, Xia G, Wang B: Induction of regulatory T cells by physiological level estrogen. J Cell Physiol 2008; 214:456464.
  • 26
    Zhao JX, Zeng YY, Liu Y: Fetal alloantigen is responsible for the expansion of the CD4(+)CD25(+) regulatory T cell pool during pregnancy. J Reprod Immunol 2007; 75:7181.
  • 27
    Zenclussen ML, Thuere C, Ahmad N, Wafula P, Fest S, Teles A, Leber A, Casalis PA, Bechmann I, Priller J, Volk HD, Zenclussen AC: The persistence of paternal antigens in the maternal body is involved in regulatory T cell expansion and fetal-maternal tolerance in murine pregnancy. Am J Reprod Immunol 2010, DOI: 10.1111/j.1600-0897.2009.00793.x.
  • 28
    Robertson SA, Guerin LR, Bromfield JJ, Branson KM, Ahlström AC, Care AS: Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biol Reprod 2009; 80:10361045.
  • 29
    Kallikourdis M, Betz AG: Periodic accumulation of regulatory T cells in the uterus: preparation for the implantation of a semi-allogeneic fetus? PLoS ONE 2007; 2:e382.
  • 30
    Arruvito L, Sanz M, Banham AH, Fainboim L: Expansion of CD4+CD25+and FOXP3+ regulatory T cells during the follicular phase of the menstrual cycle: implications for human reproduction. J Immunol 2007; 178:25722578.
  • 31
    Schumacher A, Wafula PO, Bertoja AZ, Sollwedel A, Thuere C, Wollenberg I, Yagita H, Volk HD, Zenclussen AC: Mechanisms of action of regulatory T cells specific for paternal antigens during pregnancy. Obstet Gynecol 2007; 110:11371145.
  • 32
    Moldenhauer LM, Diener KR, Thring DM, Brown MP, Hayball JD, Robertson SA: Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy. J Immunol 2009; 182:80808093.
  • 33
    Kirby DR, Billington WD, Bradbury S, Goldstein DJ: Antigen Barrier of the Mouse Placenta. Nature 1964; 204:548559.
  • 34
    Billington WD: The normal fetomaternal immune relationship. Baillieres Clin Obstet Gynaecol 1992; 6:417438.
  • 35
    Andrassy J, Kusaka S, Jankowska-Gan E, Torrealba JR, Haynes LD, Marthaler BR, Tam RC, Illigens BM, Anosova N, Benichou G, Burlingham WJ: Tolerance to noninherited maternal MHC antigens in mice. J Immunol 2003; 171:55545561.
  • 36
    Yan Z, Lambert NC, Guthrie KA, Porter AJ, Loubiere LS, Madeleine MM, Stevens AM, Hermes HM, Nelson JL: Male microchimerism in women without sons: quantitative assessment and correlation with pregnancy history. Am J Med 2005; 118:899906.
  • 37
    Tan XW, Liao H, Sun L, Okabe M, Xiao ZC, Dawe GS: Fetal microchimerism in the maternal mouse brain: a novel population of fetal progenitor or stem cells able to cross the blood-brain barrier? Stem Cells 2005; 23:14431452.
  • 38
    Khosrotehrani K, Johnson KL, Guégan S, Stroh H, Bianchi DW: Natural history of fetal cell microchimerism during and following murine pregnancy. J Reprod Immunol 2005; 66:112.
  • 39
    Dutta P, Molitor-Dart M, Bobadilla JL, Roenneburg DA, Yan Z, Torrealba JR, Burlingham WJ: Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice. Blood 2009; 114:35783587.
  • 40
    Redline RW, Lu CY: Localization of fetal major histocompatibility complex antigens and maternal leukocytes in murine placenta. Implications for maternal-fetal immunological relationship. Lab Invest 1989; 61:2736.
  • 41
    Jaffe L, Robertson EJ, Bikoff EK: Distinct patterns of expression of MHC class I and beta 2-microglobulin transcripts at early stages of mouse development. J Immunol 1991; 147:27402749.
  • 42
    Van Kampen CA, Versteeg-van der Voort Maarschalk MF, Langerak J, Van Beelen E, Roelen DL, Claas FH: Pregnancy can induce long-persisting primed CTLs specific for inherited paternal HLA antigens. Hum Immunol 2001; 62:201207.
  • 43
    Verdijk RM, Kloosterman A, Pool J, Van De Keur M, Naipal AM, Van Halteren AG, Brand A, Mutis T, Goulmy E: Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells: implications for stem cell transplantation and immunotherapy. Blood 2004; 103:19611964.
  • 44
    Van Halteren AG, Jankowska-Gan E, Joosten A, Blokland E, Pool J, Brand A, Burlingham WJ, Goulmy E: Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members. Blood 2009; 114:22632272.
  • 45
    Tafuri A, Alferink J, Möller P, Hämmerling GJ, Arnold B: T cell awareness of paternal alloantigens during pregnancy. Science 1995; 270:630633.
  • 46
    Darrasse-Jèze G, Klatzmann D, Charlotte F, Salomon BL, Cohen JL: CD4+CD25+ regulatory/suppressor T cells prevent allogeneic fetus rejection in mice. Immunol Lett 2006; 102:106109.
  • 47
    Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon DF, McCune JM: Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 2008; 322:15621565.
  • 48
    Medawar PB: Some immunological and endocrinological problems raised by evolution of viviparity in vertebrates. Symp Soc Exp Biol 1953; 7:320328.
  • 49
    Heikkinen J, Möttönen M, Alanen A, Lassila O: Phenotypic characterization of regulatory T cells in the human decidua. Clin Exp Immunol 2004; 136:373378.
  • 50
    Shevach EM, DiPaolo RA, Andersson J, Zhao DM, Stephens GL, Thornton AM: The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells. Immunol Rev 2006; 212:6073.
  • 51
    Seddon B, Mason D: Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J Exp Med 1999; 189:877882.
  • 52
    Muller-Hermelink HK, Steinmann G, Stein H: Structural and functional alterations of the aging human thymus. Adv Exp Med Biol 1982; 149:303312.
  • 53
    Kendall MD, Johnson HR, Singh J: The weight of the human thymus gland at necropsy. J Anat 1980; 131:483497.
  • 54
    Steinmann GG, Klaus B, Müller-Hermelink HK: The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study. Scand J Immunol 1985; 22:563575.
  • 55
    Aspinall R: Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J Immunol 1997; 158:30373045.
  • 56
    Nishioka T, Shimizu J, Iida R, Yamazaki S, Sakaguchi S: CD4+CD25+Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged mice. J Immunol 2006; 176:65866593.
  • 57
    Chambers SP, Clarke AG: Measurement of thymus weight, lumbar node weight and progesterone levels in syngeneically pregnant, allogeneically pregnant, and pseudopregnant mice. J Reprod Fertil 1979; 55:309315.
  • 58
    Shinomiya N, Tsuru S, Tsugita M, Katsura Y, Takemura T, Rokutanda M, Nomoto K: Thymic depletion in pregnancy: kinetics of thymocytes and immunologic capacities of the hosts. J Clin Lab Immunol 1991; 34:1122.
  • 59
    Persike EC: Involution of the thymus during pregnancy in young mice. Proc Soc Exp Biol Med 1940; 45:315317.
  • 60
    Kendall MD, Clarke AG: The thymus in the mouse changes its activity during pregnancy: a study of the microenvironment. J Anat 2000; 197:393411.
  • 61
    Clarke AG, Gil AL, Kendall MD: The effects of pregnancy on the mouse thymic epithelium. Cell Tissue Res 1994; 275:309318.
  • 62
    Maroni ES, De Sousa MA: The lymphoid organs during pregnancy in the mouse. A comparison between a syngeneic and an allogeneic mating. Clin Exp Immunol 1973; 13:107124.
  • 63
    Ito T, Hoshino T: Studies of the influences of pregnancy and lactation on the thymus in the mouse. Z Zellforsch Mikrosk Anat 1962; 57:667678.
  • 64
    Tibbetts TA, DeMayo F, Rich S, Conneely OM, O’Malley BW: Progesterone receptors in the thymus are required for thymic involution during pregnancy and for normal fertility. Proc Natl Acad Sci USA 1999; 96:1202112026.
  • 65
    Clarke AG: Pregnancy-induced involution of the thymus can be prevented by immunizing with paternal skin grafts: a strain-dependent effect. Clin Exp Immunol 1979; 35:421424.
  • 66
    Zoller AL, Schnell FJ, Kersh GJ: Murine pregnancy leads to reduced proliferation of maternal thymocytes and decreased thymic emigration. Immunology 2007; 121:207215.
  • 67
    Richters CD, Van Gelderop E, Du Pont JS, Hoekstra MJ, Kreis RW, Kamperdijk EW: Migration of dendritic cells to the draining lymph node after allogeneic or congeneic rat skin transplantation. Transplantation 1999; 67:828832.
  • 68
    Beer AE, Billingham RE: Immunobiology of mammalian reproduction. Adv Immunol 1971; 14:184.
  • 69
    Zenclussen AC, Gerlof K, Zenclussen ML, Ritschel S, Zambon Bertoja A, Fest S, Hontsu S, Ueha S, Matsushima K, Leber J, Volk HD: Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface. Eur J Immunol 2006; 36:8294.
  • 70
    Chaouat G, Kiger N, Wegmann T: Vaccination against spontaneous abortion in mice. J Reprod Immunol 1983; 5:389392.
  • 71
    Jin LP, Li DJ, Zhang JP, Wang MY, Zhu XY, Zhu Y, Meng Y, Yuan MM: Adoptive transfer of paternal antigen-hyporesponsive T cells induces maternal tolerance to the allogeneic fetus in abortion-prone matings. J Immunol 2004; 173:36123619.
  • 72
    Zhou WH, Dong L, Du MR, Zhu XY, Li DJ: Cyclosporin A improves murine pregnancy outcome in abortion-prone matings: involvement of CD80/86 and CD28/CTLA-4. Reproduction 2008; 135:385395.
  • 73
    Miranda S, Litwin S, Barrientos G, Szereday L, Chuluyan E, Bartho JS, Arck PC, Blois SM: Dendritic cells therapy confers a protective microenvironment in murine pregnancy. Scand J Immunol 2006; 64:493499.
  • 74
    Bulmer JN, Johnson PM: The T-lymphocyte population in first trimester human decidua does not express the interleukin-2 receptor. Immunology 1986; 58:685687.
  • 75
    Athanassakis I, Iconomidou B: Cytokine production in the serum and spleen of mice from day 6 to 14 of gestation: cytokines/placenta/spleen/serum. Dev Immunol 1996; 4:247255.
  • 76
    Zhu XY, Zhou YH, Wang MY, Jin LP, Yuan MM, Li DJ: Blockade of CD86 signaling facilitates a Th2 bias at the maternal-fetal interface and expands peripheral CD4+CD25+ regulatory T cells to rescue abortion-prone fetuses. Biol Reprod 2005; 72:338345.
  • 77
    Lee I, Wang L, Wells AD, Dorf ME, Ozkaynak E, Hancock WW: Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J Exp Med 2005; 201:10371044.
  • 78
    Jones RL, Hannan NJ, Kaitu’u TJ, Zhang J, Salamonsen LA: Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation. J Clin Endocrinol Metab 2004; 89:61556167.
  • 79
    Watanabe M, Shimoya K, Zhang Q, Temma-Asano K, Kimura T, Murata Y: The expression of fractalkine in the endometrium during the menstrual cycle. Int J Gynaecol Obstet 2006; 92:242247.
  • 80
    Red-Horse K, Drake PM, Gunn MD, Fisher SJ: Chemokine ligand and receptor expression in the pregnant uterus: reciprocal patterns in complementary cell subsets suggest functional roles. Am J Pathol 2001; 159:21992213.
  • 81
    Akiyama M, Okabe H, Takakura K, Fujiyama Y, Noda Y: Expression of macrophage inflammatory protein-1alpha (MIP-1alpha) in human endometrium throughout the menstrual cycle. Br J Obstet Gynaecol 1999; 106:725730.
  • 82
    Caballero-Campo P, Domínguez F, Coloma J, Meseguer M, Remohí J, Pellicer A, Simón C: Hormonal and embryonic regulation of chemokines IL-8, MCP-1 and RANTES in the human endometrium during the window of implantation. Mol Hum Reprod 2002; 8:375384.
  • 83
    Daikoku N, Kitaya K, Nakayama T, Fushiki S, Honjo H: Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle. Fertil Steril 2004; 1:876881.
  • 84
    Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY: Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005; 22:329341.
  • 85
    Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG: B cells and professional APCs recruit regulatory T cells via CCL4. Nat Immunol 2001; 2:11261132.
  • 86
    Schaniel C, Pardali E, Sallusto F, Speletas M, Ruedl C, Shimizu T, Seidl T, Andersson J, Melchers F, Rolink AG, Sideras P: Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells. J Exp Med 1998; 188:451463.
  • 87
    Tang HL, Cyster JG: Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells. Science 1999; 284:819822.
  • 88
    Camargo CA Jr, Madden JF, Gao W, Selvan RS, Clavien PA: Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology 1997; 26:15131520.
  • 89
    Iellem A, Mariani M, Lang R, Recalde H, Panina-Bordignon P, Sinigaglia F, D’Ambrosio D: Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med 2001; 194:847853.
  • 90
    Colantonio L, Iellem A, Sinigaglia F, D’Ambrosio D: Skin-homing CLA+ T cells and regulatory CD25+ T cells represent major subsets of human peripheral blood memory T cells migrating in response to CCL1/I-309. Eur J Immunol 2002; 32:35063514.
  • 91
    Ochando JC, Yopp AC, Yang Y, Garin A, Li Y, Boros P, Llodra J, Ding Y, Lira SA, Krieger NR, Bromberg JS: Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells. J Immunol 2005; 174:69937005.
  • 92
    Szanya V, Ermann J, Taylor C, Holness C, Fathman CG: The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol 2002; 169:24612465.
  • 93
    Taylor PA, Panoskaltsis-Mortari A, Swedin JM, Lucas PJ, Gress RE, Levine BL, June CH, Serody JS, Blazar BR: L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood 2004; 104:38043812.
  • 94
    Bertoja AZ, Zenclussen ML, Casalis PA, Sollwedel A, Schumacher A, Woiciechowsky C, Volk HD, Zenclussen AC: Anti-P- and E-selectin therapy prevents abortion in the CBA/J x DBA/2J combination by blocking the migration of Th1 lymphocytes into the foetal-maternal interface. Cell Immunol 2005; 238:97102.
  • 95
    Schumacher A, Brachwitz N, Sohr S, Engeland K, Langwisch S, Dolaptchieva M, Alexander T, Taran A, Malfertheiner SF, Costa SD, Zimmermann G, Nitschke C, Volk HD, Alexander H, Gunzer M, Zenclussen AC: Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. J Immunol 2009; 182:54885497.
  • 96
    Wafula PO, Teles A, Schumacher A, Pohl K, Yagita H, Volk HD, Zenclussen AC: PD-1 but not CTLA-4 blockage abrogates the protective effect of regulatory T cells in a pregnancy murine model. Am J Reprod Immunol 2009; 62:283292.
  • 97
    Read S, Greenwald R, Izcue A, Robinson N, Mandelbrot D, Francisco L, Sharpe AH, Powrie F: Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol 2006; 177:43764383.
  • 98
    Fallarino F, Grohmann U, Hwang KW, Orabona C, Vacca C, Bianchi R, Belladonna ML, Fioretti MC, Alegre ML, Puccetti P: Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol 2003; 4:12061212.
  • 99
    Miwa N, Hayakawa S, Miyazaki S, Myojo S, Sasaki Y, Sakai M, Takikawa O, Saito S: IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-gamma increase in normal pregnancy but decrease in spontaneous abortion. Mol Hum Reprod 2005; 11:865870.
  • 100
    Munn DH, Shafizadeh E, Attwood JT, Bondarev I, Pashine A, Mellor AL: Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 1999; 189:13631372.
  • 101
    Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS, Keskin DB, Marshall B, Chandler P, Antonia SJ, Burgess R, Slingluff CL, Mellor AL: Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 2002; 297:18671870.
  • 102
    Guleria I, Khosroshahi A, Ansari MJ, Habicht A, Azuma M, Yagita H, Noelle RJ, Coyle A, Mellor AL, Khoury SJ, Sayegh MH: A critical role for the programmed death ligand 1 in fetomaternal tolerance. J Exp Med 2005; 202:231237.
  • 103
    Yang Y, Huang CT, Huang X, Pardoll DM: Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol 2004; 5:508515.
  • 104
    Garin MI, Chu CC, Golshayan D, Cernuda-Morollon E, Wait R, Lechler RI: Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood 2007; 109:20582065.
  • 105
    Matarrese P, Tinari A, Mormone E, Bianco GA, Toscano MA, Ascione B, Rabinovich GA, Malorni W: Galectin-1 sensitizes resting human T lymphocytes to Fas-mediated cell death via mitochondrial hyperpolarization, budding, and fission. J Biol Chem 2005; 280:69696985.
  • 106
    Rabinovich GA, Ariel A, Hershkoviz R, Hirabayashi J, Kasai KI, Lider O: Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1. Immunology 1999; 97:100106.
  • 107
    Dias-Baruffi M, Zhu H, Cho M, Karmakar S, McEver RP, Cummings RD: Dimeric galectin-1 induces surface exposure of phosphatidylserine and phagocytic recognition of leukocytes without inducing apoptosis. J Biol Chem 2003; 278:4128241293.
  • 108
    Rabinovich GA, Iglesias MM, Modesti NM, Castagna LF, Wolfenstein-Todel C, Riera CM, Sotomayor CE: Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization. J Immunol 1998; 160:48314840.
  • 109
    Toscano MA, Commodaro AG, Ilarregui JM, Bianco GA, Liberman A, Serra HM, Hirabayashi J, Rizzo LV, Rabinovich GA: Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses. J Immunol 2006; 176:63236332.
  • 110
    Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA: Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 2009; 10:981991.
  • 111
    Oderup C, Cederbom L, Makowska A, Cilio CM, Ivars F: Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression. Immunology 2006; 118:240249.
  • 112
    Wakkach A, Fournier N, Brun V, Breittmayer JP, Cottrez F, Groux H: Characterization of dendritic cells that induce tolerance and T regulatory cell differentiation in vivo. Immunity 2003; 18:605617.
  • 113
    Lim HW, Hillsamer P, Banham AH, Kim CH: Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. J Immunol 2005; 175:41804183.
  • 114
    Gari G, Piconese S, Frossi B, Manfroi V, Merluzzi S, Tripodo C, Viola A, Odom S, Rivera J, Colombo MP, Pucillo CE: CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity 2008; 29:771781.
  • 115
    Groux H, O’Garra A, Bigler M, Rouleau M, Antonenko S, De Vries JE, Roncarolo MG: A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389:737742.
  • 116
    Weiner HL: Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev 2001; 182:207214.
  • 117
    Vigan`o P, Somigliana E, Mangioni S, Vignali M, Vignali M, Di Blasio AM: Expression of interleukin-10 and its receptor is up-regulated in early pregnant versus cycling human endometrium. J Clin Endocrinol Metab 2002; 87:57305736.
  • 118
    Inagaki N, Stern C, McBain J, Lopata A, Kornman L, Wilkinson D: Analysis of intra-uterine cytokine concentration and matrix-metalloproteinase activity in women with recurrent failed embryo transfer. Hum Reprod 2003; 18:608615.
  • 119
    Guerin LR, Prins JR, Robertson SA: Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum Reprod Update 2009; 15:517535.
  • 120
    Habicht A, Dada S, Jurewicz M, Fife BT, Yagita H, Azuma M, Sayegh MH, Guleria I: A link between PDL1 and T regulatory cells in fetomaternal tolerance. J Immunol 2007; 179:52115219.
  • 121
    Szpakowski A, Malinowski A, Cieślak J, Nowak M, Wilczyński JR, Banasik M, Szpakowski M, Tchórzewski H: Influence of paternal lymphocyte immunization on the selected subpopulations of peripheral blood lymphocytes in women with recurrent spontaneous abortions of unknown etiology. Ginekol Pol 2003; 74:288296.
  • 122
    Sugi T, Makino T, Maruyama T, Kim WK, Iizuka R: A possible mechanism of immunotherapy for patients with recurrent spontaneous abortions. Am J Reprod Immunol 1991; 25:185189.
  • 123
    Clark DA, Fernandes J, Banwatt D: Prevention of spontaneous abortion in the CBA x DBA/2 mouse model by intravaginal TGF-beta and local recruitment of CD4+8+ FOXP3+ cells. Am J Reprod Immunol 2008; 59:525534.
  • 124
    Schmidt J, Elflein K, Stienekemeier M, Rodriguez-Palmero M, Schneider C, Toyka KV, Gold R, Hünig T: Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies. J Neuroimmunol 2003; 140:143152.
  • 125
    Beyersdorf N, Gaupp S, Balbach K, Schmidt J, Toyka KV, Lin CH, Hanke T, Hünig T, Kerkau T, Gold R: Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. J Exp Med 2005; 202:445455.
  • 126
    Beyersdorf N, Hanke T, Kerkau T, Hünig T: CD28 superagonists put a break on autoimmunity by preferentially activating CD4+CD25+ regulatory T cells. Autoimmun Rev 2006; 5:4045.
  • 127
    Beyersdorf N, Balbach K, Hünig T, Kerkau T: Large-scale expansion of rat CD4+ CD25+ T(reg) cells in the absence of T-cell receptor stimulation. Immunology 2006; 119:441450.
  • 128
    Hünig T, Dennehy K: CD28 superagonists: mode of action and therapeutic potential. Immunol Lett 2005; 100:2128.
  • 129
    Rodríguez-Palmero M, Franch A, Castell M, Pelegrí C, Pérez-Cano FJ, Kleinschnitz C, Stoll G, Hünig T, Castellote C: Effective treatment of adjuvant arthritis with a stimulator y CD28-specific monoclonal antibody. J Rheumatol 2006; 33:110118.
  • 130
    Suntharalingam G, Perry MR, Ward S, Brett SJ, Castello-Cortes A, Brunner MD, Panoskaltsis N: Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006; 355:10181028.