REVIEW ARTICLE: The Immune System in Pregnancy: A Unique Complexity
Article first published online: 29 MAR 2010
© 2010 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 63, Issue 6, pages 425–433, June 2010
How to Cite
Mor, G. and Cardenas, I. (2010), REVIEW ARTICLE: The Immune System in Pregnancy: A Unique Complexity. American Journal of Reproductive Immunology, 63: 425–433. doi: 10.1111/j.1600-0897.2010.00836.x
- Issue published online: 10 MAY 2010
- Article first published online: 29 MAR 2010
- Submitted February 10, 2010; accepted February 11, 2010.
Citation Mor G, Cardenas I. The immune system in pregnancy: a unique complexity. Am J Reprod Immunol 2010
Placental immune response and its tropism for specific viruses and pathogens affect the outcome of the pregnant woman’s susceptibility to and severity of certain infectious diseases. The generalization of pregnancy as a condition of immune suppression or increased risk is misleading and prevents the determination of adequate guidelines for treating pregnant women during pandemics. There is a need to evaluate the interaction of each specific pathogen with the fetal/placental unit and its responses to design the adequate prophylaxis or therapy. The complexity of the immunology of pregnancy and the focus, for many years, on the concept of immunology of pregnancy as an organ transplantation have complicated the field and delayed the development of new guidelines with clinical implications that could help to answer these and other relevant questions. Our challenge as scientists and clinicians interested in the field of reproductive immunology is to evaluate many of the ‘classical concepts’ to define new approaches for a better understanding of the immunology of pregnancy that will benefit mothers and fetuses in different clinical scenarios.