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Placental Interleukin-15 Expression in Recurrent Miscarriage


Bettina Toth, Department of Gynecological Endocrinology and Fertility Disorders, Ruprechts-Karls University, Heidelberg, Germany.


Citation Toth B, Haufe T, Scholz C, Kuhn C, Friese K, Karamouti M, Makrigiannakis A, Jeschke U. Placental Interleukin-15 expression in recurrent miscarriage. Am J Reprod Immunol 2010; 64: 402–410

Problem  Cytokines play a fundamental role at the feto–maternal interface. A dysregulation of the cytokine profile could be linked with fetal rejection. This study investigated differences in the expression of the Th1 cytokine interleukin-15 (IL-15) of normal and disturbed pregnancy.

Method of study  Analysis of IL-15 expression by immunohistochemistry and real-time RT-PCR in placental tissue from normal pregnancies, spontaneous miscarriage and recurrent miscarriage (RM) was performed.

Results  Expression of IL-15 was upregulated on mRNA and protein level in the placenta of miscarriage patients, especially in patients with RM. Immunohistochemistry and immunofluorescence double staining revealed extravillous trophoblast cells (EVT) as IL-15-expressing cells. Staining results were confirmed by real-time PCR (TaqMan).

Conclusion  Increased expression of IL-15 in the decidua of patients with RM may be linked to disturbed implantation and vascularization with consecutive placental and fetal rejection.