Association of Peroxisome Proliferator-Activated Receptor-Gamma 2 Pro12Ala Polymorphism with Advanced-Stage Endometriosis
Article first published online: 17 JUN 2010
© 2010 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 64, Issue 5, pages 333–338, November 2010
How to Cite
Hwang, K. R., Choi, Y. M., Kim, J. M., Lee, G. H., Kim, J. J., Chae, S. J. and Moon, S. Y. (2010), Association of Peroxisome Proliferator-Activated Receptor-Gamma 2 Pro12Ala Polymorphism with Advanced-Stage Endometriosis. American Journal of Reproductive Immunology, 64: 333–338. doi: 10.1111/j.1600-0897.2010.00882.x
- Issue published online: 17 JUN 2010
- Article first published online: 17 JUN 2010
- Submitted February 19, 2010; accepted April 18, 2010.
Citation Hwang KR, Choi YM, Kim JM, Lee GH, Kim JJ, Chae SJ, Moon SY. Association of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism with advanced-stage endometriosis. Am J Reprod Immunol 2010
To investigate whether the peroxisome proliferator-activated receptor (PPAR)-γ2 Pro12Ala polymorphism is associated with a risk of advanced-stage endometriosis in a Korean population.
Methods of study Case–control study in a collective of 446 patients and 427 controls. The Pro12Ala polymorphism of PPAR-γ2 gene was genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis.
Results The distribution of the PPAR-γ2 Pro12Ala polymorphism was different between the advanced-stage endometriosis group and the control group (non-CC rates were 5.2% for patients with advanced endometriosis and 10.1% for the control group, respectively, P = 0.006). The frequency for the Ala-12 allele variant was significantly lower in patients with advanced stage of endometriosis (2.7%) than in the control group (5.3%) (P = 0.006).
Conclusion These findings suggest that the PPAR-γ2 Pro12Ala polymorphism is associated with advanced-stage endometriosis in the Korean population. Unlike results from other studies reported so far, the Ala-12 allele may have protective effects against advanced-stage endometriosis in the Korean population.