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IL-17 Increased in the Third Trimester in Healthy Women with Term Labor

Authors

  • Erika A. Martínez-García,

    1. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México
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  • Bernardo Chávez-Robles,

    1. Hospital Versalles, Av Alcalde 2170 Col Santa Monica, Guadalajara, Jalisco, México
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  • Pedro E. Sánchez-Hernández,

    1. Laboratorio de Inmunología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México
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  • Lourdes Núñez-Atahualpa,

    1. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México
    2. Universidad Autónoma de Guadalajara, Jalisco, México
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  • Beatriz T. Martín-Máquez,

    1. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México
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  • Andrea Muñoz-Gómez,

    1. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México
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  • Laura González-López,

    1. Hospital Regional General 110, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México
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  • Jorge I. Gámez-Nava,

    1. Unidad de Investigación Médica en Epidemiología Clínica, Centro Médico de Occidente, Instituto Mexicano del Seguro Social. Guadalajara, Jalisco, México
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  • Mario Salazar-Páramo,

    1. Unidad de Investigación Médica en Epidemiología Clínica, Centro Médico de Occidente, Instituto Mexicano del Seguro Social. Guadalajara, Jalisco, México
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  • Ingrid Dávalos-Rodríguez,

    1. Instituto de Genética Humana, Depto. de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, CIBO, IMSS
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  • Marcelo H. Petri,

    1. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México
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  • Diego Zúñiga-Tamayo,

    1. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México
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  • Raúl Vargas-Ramírez,

    1. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México
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  • Mónica Vázquez-Del Mercado

    1. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México
    2. Depto de Reumatologia, Division de Medicina Interna, Hospital Civil Juan I. Menchaca
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Mónica Vázquez-Del Mercado MD, PhD, Rheumatology, Directora, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada # 950, Puerta 7, Planta baja, Edificio P, Colonia Independencia, Guadalajara, P.O. Box 2-207, Jalisco, México.
E-mail: dravme@hotmail.com

Abstract

Citation Martínez-García EA, Chávez-Robles B, Sánchez-Hernández PE, Nuñez-Atahualpa L, Martín-Máquez BT, Muñoz-Gómez A, González-López L, Gámez-Nava JI, Salazar-Páramo M, Dávalos-Rodríguez I, Petri MH, Zuñiga-Tamayo D, Vargas-Ramírez R, Vázquez-Del Mercado M. IL-17 Increased in the third trimester in healthy women with term labor. Am J Reprod Immunol 2011; 65: 99–103

Introduction  The function, peripheral blood expression, and physiologic importance of IL-17 is not well established. Detection of IL-17 in sera and plasma samples from patients with pre-eclampsia has been reported with inconsistent results. To establish the l levels of the IL-17 at peripheral level, we studied prospectively a cohort of 13 healthy pregnant women.

Objective  To evaluate the changes in serum levels of IL-17 in healthy pregnant women in a prospective cohort.

Material and Methods  Thirteen healthy pregnant women were prospectively followed to evaluate serum levels of IL-17. Each patient was evaluated at each trimester. IL-17 levels were measured by ELISA. The statistical analysis was done using repeated measures anova and Bonferroni′s multiple comparison test.

Results  IL-17 levels were significantly increased from first trimester with a mean of 14.61 up to 31.78 pg/mL at third trimester (P < 0.05), but when detectable, they were almost identical range in all trimesters.

Conclusions  We propose that IL-17 levels in healthy women are present with very similar range levels during the whole pregnancy but the average is increased during the third trimester maybe as a part of the complex network of cytokines as a result of implantation, fetal development, and labor process itself.

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