Are Educators at High Risk of Sub-fertility? A Multicenter Study
Version of Record online: 15 AUG 2010
© 2010 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 65, Issue 4, pages 415–420, April 2011
How to Cite
Perros, G., Tzonis, P., Tsilivakos, V., Gerofotis, A., Dalavitsou, V., Vassilaki, A., Keramitsoglou, T., Papaioannou, D., Moschandreou, D., Kontopoulou-Antonopoulou, V., Daniilidis, M. and Varla-Leftherioti, M. (2011), Are Educators at High Risk of Sub-fertility? A Multicenter Study. American Journal of Reproductive Immunology, 65: 415–420. doi: 10.1111/j.1600-0897.2010.00905.x
- Issue online: 4 MAR 2011
- Version of Record online: 15 AUG 2010
- Submitted March 12, 2010; accepted June 28, 2010.
- NK cells;
- occupational diseases;
- virous infections
Citation Perros G, Tzonis P, Tsilivakos V, Gerofotis A, Dalavitsou V, Vassilaki A, Keramitsoglou T, Papaioannou D, Moschandreou D, Kontopoulou-Antonopoulou V, Daniilidis M, Varla-Leftherioti M. Are educators at high risk of sub-fertility? A multicenter study. Am J Reprod Immunol 2011; 65: 415–420
Problem A high percentage of women schoolteachers having fertility problems were observed by three independent teams.
Method Expected percentage of educators was calculated in 4650 sub-fertile women and 2,062,891 women at reproductive age. To explore the possibility that schoolteachers’ contact with childhood viral infections results in alterations of peripheral blood natural killer (NK) cells, a multiple linear regression analysis for profession, age, difficulty to conceive, number of abortions/implantation failures (predictor variables) was performed in childless educators (210) and housewives (184).
Results The difference between observed and expected percentage of sub-fertile schoolteachers was statistically significant (17.6% vs 6.86%, P < 0.0001). The mean percentage of PB NK cells was slightly higher in educators compared to housewives (12.48% vs 11.56%, P = 0.10), and the multiple linear regression analysis revealed that the profession (schoolteacher or not) was the only predictive variable for higher NK% values (P = 0.044).
Conclusion Teachers’ sub-fertility appears as an ‘occupational disease’. Τhe possibility that results from their exposure to childhood viral infections has to be further explored.