The Interface of the Immune and Reproductive Systems in the Ovary: Lessons Learned from the Corpus Luteum of Domestic Animal Models

Authors

  • Joy L. Pate,

    1. Department of Dairy and Animal Science, Center for Reproductive Biology and Health, The Pennsylvania State University, State College, PA, USA
    Search for more papers by this author
  • Koji Toyokawa,

    1. Department of Dairy and Animal Science, Center for Reproductive Biology and Health, The Pennsylvania State University, State College, PA, USA
    Search for more papers by this author
  • Sadhat Walusimbi,

    1. Department of Dairy and Animal Science, Center for Reproductive Biology and Health, The Pennsylvania State University, State College, PA, USA
    Search for more papers by this author
  • Edyta Brzezicka

    1. Department of Dairy and Animal Science, Center for Reproductive Biology and Health, The Pennsylvania State University, State College, PA, USA
    Search for more papers by this author

Joy L. Pate, 324 Henning Building, University Park, PA 16802, USA.
E-mail: jlp36@psu.edu

Abstract

Citation Pate JL, Toyokawa K, Walusimbi S, Brzezicka E. The interface of the immune and reproductive systems in the ovary: lessons learned from the corpus luteum of domestic animal models. Am J Reprod Immunol 2010

The dynamic changes that characterize the female reproductive system are regulated by hormones. However, local cell-to-cell interactions may mediate responsiveness of tissues to hormonal signals. The corpus luteum (CL) is an excellent model for understanding how immune cells are recruited into tissues and the role played by those cells in regulating tissue homeostasis or demise. Leukocytes are recruited into the CL throughout its lifespan, and leukocyte-derived cytokines have been found in corpora lutea of all species examined. The proinflammatory cytokines inhibit gonadotropin-stimulated steroidogenesis, profoundly stimulate prostaglandin synthesis by luteal cells, and promote apoptosis. However, there is mounting evidence that leukocytes and luteal cells communicate in different ways to maintain homeostasis within the functional CL. Domestic animals have provided important information regarding the presence and role of immune cells in the CL.

Ancillary