The Interface of the Immune and Reproductive Systems in the Ovary: Lessons Learned from the Corpus Luteum of Domestic Animal Models
Article first published online: 16 AUG 2010
© 2010 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Special Issue: Special Issue on Domestic Animal Models of Reproductive Immunology
Volume 64, Issue 4, pages 275–286, October 2010
How to Cite
Pate, J. L., Toyokawa, K., Walusimbi, S. and Brzezicka, E. (2010), The Interface of the Immune and Reproductive Systems in the Ovary: Lessons Learned from the Corpus Luteum of Domestic Animal Models. American Journal of Reproductive Immunology, 64: 275–286. doi: 10.1111/j.1600-0897.2010.00906.x
- Issue published online: 2 SEP 2010
- Article first published online: 16 AUG 2010
- Submitted April 14, 2010; accepted June 30, 2010.
- Corpus luteum;
- lymphocytes and luteal function;
- resident leukocytes
Citation Pate JL, Toyokawa K, Walusimbi S, Brzezicka E. The interface of the immune and reproductive systems in the ovary: lessons learned from the corpus luteum of domestic animal models. Am J Reprod Immunol 2010
The dynamic changes that characterize the female reproductive system are regulated by hormones. However, local cell-to-cell interactions may mediate responsiveness of tissues to hormonal signals. The corpus luteum (CL) is an excellent model for understanding how immune cells are recruited into tissues and the role played by those cells in regulating tissue homeostasis or demise. Leukocytes are recruited into the CL throughout its lifespan, and leukocyte-derived cytokines have been found in corpora lutea of all species examined. The proinflammatory cytokines inhibit gonadotropin-stimulated steroidogenesis, profoundly stimulate prostaglandin synthesis by luteal cells, and promote apoptosis. However, there is mounting evidence that leukocytes and luteal cells communicate in different ways to maintain homeostasis within the functional CL. Domestic animals have provided important information regarding the presence and role of immune cells in the CL.