Thyroid Autoimmunity and its Association with Cellular and Humoral Immunity in Women with Reproductive Failures

Authors

  • Na Young Kim,

    1. Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science. North Chicago, IL, USA
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  • Hye Jin Cho,

    1. Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science. North Chicago, IL, USA
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  • Heun Yun Kim,

    1. Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science. North Chicago, IL, USA
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  • Kwang Moon Yang,

    1. Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science. North Chicago, IL, USA
    2. Department of Obstetrics and Gynecology, Cheil General Hospital & Women’s Healthcare Center, Kwandong University, College of Medicine, Seoul, Korea
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  • Hyun Kyong Ahn,

    1. Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science. North Chicago, IL, USA
    2. Department of Obstetrics and Gynecology, Cheil General Hospital & Women’s Healthcare Center, Kwandong University, College of Medicine, Seoul, Korea
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  • Simon Thornton,

    1. CARE Fertility, Nottingham, UK
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  • Joon Cheol Park,

    1. Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science. North Chicago, IL, USA
    2. Department of Obstetrics and Gynecology, Dongsan Medical Center, Keimyung University, School of Medicine, Daegu, Korea
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  • Kenneth Beaman,

    1. Department of Microbiology and Immunology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science. North Chicago, IL, USA
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  • Alice Gilman-Sachs,

    1. Department of Microbiology and Immunology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science. North Chicago, IL, USA
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  • Joanne Kwak-Kim

    1. Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science. North Chicago, IL, USA
    2. Department of Microbiology and Immunology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science. North Chicago, IL, USA
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Joanne Kwak-Kim, Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School/Rosalind Franklin University of Medicine and Science, 830 West End Ct. Suite 400, Vernon Hills, IL 60061, USA.
E-mail: Joanne.kwakkim@rosalindfranklin.edu

Abstract

Citation Kim NY, Cho HJ, Kim HY, Yang KM, Ahn HK, Thornton S, Park JC, Beaman K, Gilman-Sachs A, Kwak-Kim J. Thyroid autoimmunity and its association with cellular and humoral immunity in women with reproductive failures. Am J Reprod Immunol 2011; 65: 78–87

Problem  Thyroid autoimmunity (TAI), which is T helper (Th)1-cell-mediated autoimmunity to thyrocytes, is associated with increased risk of miscarriages and highly prevalent in women with infertility. We aim at investigating the prevalence of TAI in women with recurrent spontaneous abortions (RSA) or unexplained infertility (UI) and its relationship with cellular and humoral immune abnormalities.

Method of study  Prevalence of antiphospholipid antibodies, anti-nuclear antibody, other non-organ-specific antibodies (NOSAs; anti-dsDNA, anti-ssDNA, anti-histone, anti-Scl70), peripheral blood natural killer (NK) cell levels (%) and cytotoxicity, and CD3+/CD4+ Th1/Th2 cell ratios were compared in women with and without TAI. Thyroid functional tests (TFT) were analyzed in both groups before and after pregnancy.

Results  Tumor necrosis factor-α/IL-10 expressing CD3+/CD4+ cell ratios (P < 0.05), CD56+ NK cell levels (P < 0.05), the prevalence of anticardiolipin antibodies (< 0.05) and other NOSAs (< 0.005) were significantly higher in women with TAI when compared to women without TAI. Changes in thyroid-stimulating hormone levels between before and after pregnancy in women with TAI were significantly higher when compared to those of women without TAI (< 0.05).

Conclusion  TAI is associated with impaired cellular and humoral immune responses in women with RSA or UI. In women with TAI, serial TFT is recommended when pregnancy is established.

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