• 1
    Moor RM: Foetal homeostasis: conceptus-ovary endocrine balance. Proc R Soc Med 1968; 61:12171226.
  • 2
    Murphy BD, Silavin SL: Luteotrophic agents and steroid substrate utilization. Oxf Rev Reprod Biol 1989; 11:179223.
  • 3
    Banerjee P, Fazleabas AT: Endometrial responses to embryonic signals in the primate. Int J Dev Biol 2010; 54:295302.
  • 4
    Ehrenkranz JR: Home and point-of-care pregnancy tests: a review of the technology. Epidemiol 2002; 13:S15S18.
  • 5
    Stewart HJ: Trophoblastic factors and the maternal recognition of pregnancy in sheep and cattle. J Dev Physiol 1990; 14:115123.
  • 6
    Bazer FW, Wu G, Spencer TE, Johnson GA, Burghardt RC, Bayless K: Novel pathways for implantation and establishment and maintenance of pregnancy in mammals. Mol Hum Reprod 2010; 16:135152.
  • 7
    Godkin JD, Bazer FW, Roberts RM: Ovine trophoblast protein 1, an early secreted blastocyst protein, binds specifically to uterine endometrium and affects protein synthesis. Endocrinology 1984; 114:120130.
  • 8
    Schalue-Francis TK, Farin PW, Cross JC, Keisler D, Roberts RM: Effect of injected bovine interferon-α11 on oestrous cycle length and pregnancy success in sheep. J Reprod Fertil 1991; 91:347356.
  • 9
    Lamming GE, Wathes DC, Flint AP, Payne JH, Stevenson KR, Vallet JL: Local action of interferons in suppression of the development of oxytocin and oestradiol receptors in ovine endometrium. J Reprod Fertil 1995; 105:165175.
  • 10
    Kazemi M, Malathy PV, Keisler DH, Roberts RM: Ovine trophoblast protein-1 and bovine trophoblast protein-1 are present as specific components of uterine flushings of pregnant ewes and cows. Biol Reprod 1988; 39:457463.
  • 11
    Verstegen-Onclin K, Verstegen J: Endocrinology of pregnancy in the dog: a review. Theriogenology 2008; 70:291299.
  • 12
    Oliveira LJ, Hansen PJ: Deviations in populations of peripheral blood mononuclear cells and endometrial macrophages in the cow during pregnancy. Reproduction 2008; 136:481490.
  • 13
    Croy A: Cellular and molecular events in early and mid gestation porcine implantation sites: a review. Proc Soc Study Fertil 2009; 66:233244.
  • 14
    De Mestre A, Noronha L, Wagner B, Antczak DF: Split immunological tolerance to trophoblast. Int J Dev Biol 2010; 54:445455.
  • 15
    Arck P, Hansen PJ, Mulac Jericevic B, Piccinni MP, Szekeres-Bartho J: Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress. Am J Reprod Immunol 2007; 58:268279.
  • 16
    Tsampalas M, Gridelet V, Berndt S, Foidart JM, Geenen V, Perrier d’Hauterive S: Human chorionic gonadotropin: a hormone with immunological and angiogenic properties. J Reprod Immunol 2010; 85:9398.
  • 17
    Maston GA, Ruvolo M: Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. Mol Biol Evol 2002; 19:320335.
  • 18
    Knox K, Baker JC: Genomic evolution of the placenta using co-option and duplication and divergence. Genome Res 2008; 18:695705.
  • 19
    Siiteri PK, Stites DP: Immunologic and endocrine interrelationships in pregnancy. Biol Reprod 1982; 26:114.
  • 20
    Wegmann T, Lin H, Guilbert L, Mosmann T: Bidirectional interactions in the maternal–fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 15:353356.
  • 21
    Lin H, Mossmann T, Guilbert L, Tuntipopipat S, Wegmann T: Synthesis of T helper 2-type cytokines at the maternal–fetal interface. J Immunol 1993; 151:45624573.
  • 22
    Dosiou C, Giudice L: Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives. Endocr Rev 2005; 26:4462.
  • 23
    Liu J, Lojun S, Lei Z, Wu W, Peiner S, Rao C: Lymphocytes from pregnant women express human chorionic gonadotropin/luteinizing hormone receptor gene. Mol Cell Endocrinol 1995; 111:R13R17.
  • 24
    Raghupathy R: Maternal anti-placental cell-mediated reactivity and spontaneous abortions. Am J Reprod Immunol 1997; 37:478484.
  • 25
    McCracken SA, Gallery E, Morris JM: Pregnancy-specific down-regulation of NF-kappa B expression in T cells in humans is essential for the maintenance of the cytokine profile required for pregnancy success. J Immunol 2004; 172:45834591.
  • 26
    Huber AV, Saleh L, Prast J, Haslinger P, Knofler M: Human chorionic gondadotropin attenuates NF-κB activation and cytokine expression of endometriotic stromal cells. Mol Hum Reprod 2007; 13:595604.
  • 27
    Fuchs T, Hammarström L, Smith CI, Brundin J: Sex-dependent induction of human suppressor T cells by chorionic gonadotropin. J Reprod Immunol 1982; 4:185190.
  • 28
    Han T: Inhibitory effect of human chorionic gonadotrophin on lymphocyte blastogenic response to mitogen, antigen and allogeneic cells. Clin Exp Immunol 1974; 18:529535.
  • 29
    Hammarstrom L, Fuchs T, Smith C: The immunodepressive effect of human glucoproteins and their possible role in the nonrejection process during pregnancy. Acta Obstet Gynecol Scand 1979; 58:417422.
  • 30
    Carbone F, Procaccini C, De Rosa V, Alviggi C, De Placido G, Kramer D, Longobardi S, Matarese G: Divergent immunomodulatory effects of recombinant and urinary-derived FSH, LH, and hCG on human CD4(+) T cells. J Reprod Immunol 2010; 85:172179.
  • 31
    Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A, Saito S: Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod 2004; 10:347353.
  • 32
    Schumacher A, Brachwitz N, Sohr S, Engeland K, Langwisch S, Dolaptchieva M, Alexander T, Taran A, Malfertheiner S, Costa S, Zimmermann G, Nitschke C, Volk H, Alexander H, Gunzer M, Zenclussen A: Human chorionic gonadotropin attracts regulatory T cells into the fetal–maternal interface during early human pregnancy. J Immunol 2009; 182:54885497.
  • 33
    Wan H, Versnel MA, Leijten LM, Van Helden-Meeuwsen CG, Fekkes D, Leenen PJ, Khan NA, Benner R, Kiekens RC: Chorionic gonadotropin induces dendritic cells to express a tolerogenic phenotype. J Leukoc Biol 2008; 83:894901.
  • 34
    Miyaura H, Iwata M: Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids. J Immunol 2002; 168:10871094.
  • 35
    SundarRaj S, Mukhopadhyay D, Karande AA: Glycodelin A triggers mitochondrial stress and apoptosis in T cells by a mechanism distinct and independent of TCR signaling. Mol Immunol 2008; 45:23912400.
  • 36
    Lea RG, Sandra O: Immunoendocrine aspects of endometrial function and implantation. Reproduction 2007; 134:389404.
  • 37
    Chaouat G: Current knowledge on natural killer cells, pregnancy and pre-eclampsia. Introduction. Reprod Biomed Online 2008; 16:170172.
  • 38
    Germain S, Sacks G, Sooranna S, Sargent I, Redman C: Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles. J Immunol 2007; 178:59495956.
  • 39
    Saito S, Sakai M, Sasaki Y, Nakashima A, Shiozaki A: Inadequate tolerance induction may induce pre-eclampsia. J Reprod Immunol 2007; 76:3039.
  • 40
    Sacks G, Sargent I, Redman C: An innate view of human pregnancy. Immunol Today 1999; 20:114118.
  • 41
    Chaouat G: The Th1/Th2 paradigm: still important in pregnancy? Semin Immunopathol 2007; 29:95113.
  • 42
    Sherwin JR, Sharkey AM, Cameo P, Mavrogianis PM, Catalano RD, Edassery S, Fazleabas AT: Identification of novel genes regulated by chorionic gonadotropin in baboon endometrium during the window of implantation. Endocrinology 2007; 148:618626.
  • 43
    Kosaka K, Fujiwara H, Tatsumi K, Yoshioka S, Sato Y, Egawa H, Higuchi T, Nakayama T, Ueda M, Maeda M, Fujii S: Human chorionic gonadotropin (HCG) activates monocytes to produce interleukin-8 via a different pathway from luteinizing hormone/HCG receptor system. J Clin Endocrinol Metab 2002; 87:51995208.
  • 44
    Shibuya T, Izuchi K, Kuroiwa A, Okabe N, Shirakawa K: Study on nonspecific immunity in pregnant women: increased chemiluminescence response of peripheral blood phagocytes. Am J Reprod Immunol Microbiol 1987; 15:1923.
  • 45
    Fujiwara H: Do circulating blood cells contribute to maternal tissue remodeling and embryo-maternal cross-talk around the implantation period? Mol Hum Reprod 2009; 15:335343.
  • 46
    Hashii K, Fujiwara H, Yoshioka S, Kataoka N, Yamada S, Hirano T, Mori T, Fujii S, Maeda M: Peripheral blood mononuclear cells stimulate progesterone production by luteal cells derived from pregnant and non-pregnant women: possible involvement of interleukin-4 and interleukin-10 in corpus luteum function and differentiation. Hum Reprod 1998; 13:27382744.
  • 47
    Nakayama T, Fujiwara H, Maeda M, Inoue T, Yoshioka S, Mori T, Fujii S: Human peripheral blood mononuclear cells (PBMC) in early pregnancy promote embryo invasion in vitro: HCG enhances the effects of PBMC. Hum Reprod 2002; 17:207212.
  • 48
    Egawa H, Fujiwara H, Hirano T, Nakayama T, Higuchi T, Tatsumi K, Mori T, Fujii S: Peripheral blood mononuclear cells in early pregnancy promote invasion of human choriocarcinoma cell line, BeWo cells. Hum Reprod 2002; 17:473480.
  • 49
    Alexander H, Zimmermann G, Lehmann M, Pfeiffer R, Schone E, Leiblein S, Ziegert M: HCG secretion by peripheral mononuclear cells during pregnancy. Domest Anim Endocrinol 1998; 15:377387.
  • 50
    Kosaka K, Fujiwara H, Tatsumi K, Yoshioka S, Higuchi T, Sato Y, Nakayama T, Fuji S: Human peripheral blood mononuclear cells enhance cell–cell interaction between human endometrial epithelial cells and BeWo-cell spheroids. Hum Reprod 2003; 18:1925.
  • 51
    Yoshioka S, Fujiwara H, Nakayama T, Kosaka K, Mori T, Fujii S: Intrauterine administration of autologous peripheral blood mononuclear cells promotes implantation rates in patients with repeated failure of IVF-embryo transfer. Hum Reprod 2006; 21:32903294.
  • 52
    Bourinbaiar AS, Nagorny R: Inhibitory effect of human chorionic gonadotropin (hCG) on HIV-1 transmission from lymphocytes to trophoblasts. FEBS Lett 1992; 309:8284.
  • 53
    Bourinbaiar AS, Lee-Huang S: Anti-HIV effect of beta subunit of human chorionic gonadotropin (beta hCG) in vitro. Immunol Lett 1995; 44:1318.
  • 54
    Bourinbaiar AS, Powell JE, Stevens VC: The role of carboxy-terminal portion of beta subunit of human chorionic gonadotropin in human immunodeficiency virus infection. Life Sci 1997; 61:149157.
  • 55
    Lee-Huang S, Huang PL, Sun Y, Huang PL, Kung HF, Blithe DL, Chen HC: Lysozyme and RNases as anti-HIV components in b-core preparations of human chorionic gonadotropin. Proc Natl Acad Sci USA 1999; 96:26782681.
  • 56
    Gunn LK, Homa ST, Searle MJ, Chard T: Lack of evidence for the production of interferon-alpha-like species by the cultured human pre-embryo. Hum Reprod 1994; 9:15221527.
  • 57
    Roberts RM, Chen Y, Ezashi T, Walker AM: Interferons and the maternal-conceptus dialog in mammals. Semin Cell Dev Biol 2008; 19:170177.
  • 58
    Bebington C, Bell SC, Doherty FJ, Fazleabas AT, Fleming SD: Localization of ubiquitin and ubiquitin cross-reactive protein in human and baboon endometrium and decidua during the menstrual cycle and early pregnancy. Biol Reprod 1999; 60:920928.
  • 59
    Harty RN, Pitha PM, Okumura A: Antiviral activity of innate immune protein ISG15. J Innate Immun 2009; 1:397404.
  • 60
    Austin K, Bany B, Belden E, Rempel L, Cross J, Hansen T: Interferon-stimulated gene-15 (Isg15) expression is up-regulated in the mouse uterus in response to the implanting conceptus. Endocrinology 2003; 144:31073113.
  • 61
    Austin K, Carr A, Pru J, Hearne C, George E, Belden E, Hansen T: Localization of ISG15 and conjugated proteins in bovine endometrium using immunohistochemistry and electron microscopy. Endocrinology 2004; 145:967975.
  • 62
    Han H, Austin K, Rempel L, Hansen T: Low blood ISG15 mRNA and progesterone levels are predictive of non-pregnant dairy cows. J Endocrinol 2006; 191:505512.
  • 63
    Gifford CA, Racicot K, Clark DS, Austin KJ, Hansen TR, Lucy MC, Davies CJ, Ott TL: Regulation of interferon-stimulated genes in peripheral blood leukocytes in pregnant and bred, nonpregnant dairy cows. J Dairy Sci 2007; 90:274280.
  • 64
    Komorowski J, Gradowski G, Stepień H: Effects of hCG and beta-hCG on IL-2 and sIL-2R secretion from human peripheral blood mononuclear cells: a dose-response study in vitro. Immunol Lett 1997; 59:2933.
  • 65
    Van der Zee M, Dik WA, Kap YS, Dillon MJ, Benner R, Leenen PJ, Khan NA, Drevets DA: Synthetic human chorionic gonadotropin-related oligopeptides impair early innate immune responses to Listeria monocytogenes in mice. J Infect Dis 2010; 201:10721080.
  • 66
    Robbins JR, Skrzypczynska KM, Zeldovich VB, Kapidzic M, Bakardjiev AI: Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes. PLoS Pathog 2010; 6:e1000732.
  • 67
    Yoshimura T, Inaba M, Sugiura K, Nakajima T, Ito T, Nakamura K, Kanzaki H, Ikehara S: Analyses of dendritic cell subsets in pregnancy. Am J Reprod Immunol 2003; 50:137145.
  • 68
    Segerer SE, Müller N, Van Den Brandt J, Kapp M, Dietl J, Reichardt HM, Rieger L, Kämmerer U: Impact of female sex hormones on the maturation and function of human dendritic cells. Am J Reprod Immunol 2009; 62:165173.
  • 69
    Bazer FW: Mediators of maternal recognition of pregnancy in mammals. PSEBM 1992; 199:373384.
  • 70
    Imakawa K, Anthony RV, Kazemi M, Marotti KR, Polites HG, Roberts RM: Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm. Nature 1987; 330:377379.
  • 71
    Ott T, Van Heeke G, Johnson H, Bazer F: Cloning and expression in Saccharomyces cerevisiae of a synthetic gene for the Type-1 trophoblast interferon ovine trophoblast protein-1: purification and antiviral activity. J Interferon Res 1991; 11:357364.
  • 72
    Ott TL, Fleming JG, Spencer TE, Joyce MM, Chen P, Green CN, Zhu D, Welsh Jr TH, Harms PG, Bazer FW: Effects of exogenous recombinant ovine interferon tau on circulating concentrations of progesterone, cortisol, luteinizing hormone, and antiviral activity; interestrous interval; rectal temperature; and uterine response to oxytocin in cyclic ewes. Biol Reprod 1997; 57:621629.
  • 73
    Thatcher W, Meyer M, Danet-Desnoyers G: Maternal recognition of pregnancy. J Reprod Fertil Suppl 1995; 49:1528.
  • 74
    Yankey S, Hicks B, Carnahan K, Assiri A, Sinor S, Kodali K, Stellflug J, Ott T: Expression of the antiviral protein Mx in peripheral blood mononuclear cells of pregnant and bred, non-pregnant ewes. J Endocrinol 2001; 170:R7R11.
  • 75
    Oliveira JF, Henkes LE, Ashley RL, Purcell SH, Smirnova NP, Veeramachaneni DN, Anthony RV, Hansen TR: Expression of interferon (IFN)-stimulated genes in extrauterine tissues during early pregnancy in sheep is the consequence of endocrine IFN-tau release from the uterine vein. Endocrinology 2008; 149:12521259.
  • 76
    Bott RC, Ashley RL, Henkes LE, Antoniazzi AQ, Bruemmer JE, Niswender GD, Bazer FW, Spencer TE, Smirnova NP, Anthony RV, Hansen TR: Uterine vein infusion of interferon tau (IFNT) extends luteal life span in ewes. Biol Reprod 2010; 82:725735.
  • 77
    Stevenson JL, Dalton JC, Ott TL, Racicot KE, Chebel RC: Correlation between reproductive status and steady-state mRNA levels of the Myxovirus resistance gene, MX2, in peripheral blood leukocytes of dairy heifers. J Anim Sci 2007; 85:21632172.
  • 78
    Tuo W, Brown W, Roger E, Zhu D, Lin G, Smith R, Bazer F: Trophoblast interferon tau differentially induces lymphopenia and neutropenia in lambs. J Interferon Cytokine Res 1998; 18:731737.
  • 79
    Gierek D, Baczyńska D, Ugorski M, Bazer F, Kurpisz M, Bednarski T, Gorczykowski M, Chełmońska-Soyta A: Differential effect of IFN-tau on proliferation and distribution of lymphocyte subsets in one-way mixed lymphocyte reaction in cows and heifers. J Reprod Immunol 2006; 71:126131.
  • 80
    Niwano Y, Hansen TR, Kazemi M, Malaty PV, Johnson HD, Roberts RM, Imakawa K: Suppression of T-lymphocyte blastogenesis by ovine trophoblast protein-1 and human interferon-a may be independent of interleukin-2 production. Am J Reprod Immunol 1989; 20:2126.
  • 81
    Tekin S, Hansen PJ: Natural killer-like cells in the sheep: functional characterization and regulation by pregnancy-associated proteins. Exp Biol Med (Maywood) 2002; 227:803811.
  • 82
    Gifford CA, Assiri AM, Satterfield MC, Spencer TE, Ott TL: Receptor transporter protein 4 (RTP4) in endometrium, ovary, and peripheral blood leukocytes of pregnant and cyclic ewes. Biol Reprod 2008; 79:518524.
  • 83
    Nagaoka K, Sakai A, Nojima H, Suda Y, Yokomizo Y, Imakawa K, Sakai S, Christenson RK: A chemokine, interferon (IFN)-gamma-inducible protein 10 kDa, is stimulated by IFN-tau and recruits immune cells in the ovine endometrium. Biol Reprod 2003; 68:14131421.
  • 84
    Borroni E, Mantovani A, Locati M, Bonecchi R: Chemokine receptors intracellular trafficking. Pharmacol Ther 2010; 127:18.