Get access

Immunologic Characteristics of Preeclampsia, a Comprehensive Review

Authors

  • Hyunkyong Ahn,

    1. Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    2. Department of Obstetrics and Gynecology, Cheil General Hospital & Women’s Healthcare Center, Kwandong University College of Medicine, Seoul, Korea
    Search for more papers by this author
  • Jooncheol Park,

    1. Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    2. Department of Obstetrics and Gynecology, School of Medicine, Keimyung University, Daegu, Korea
    Search for more papers by this author
  • Alice Gilman-Sachs,

    1. Department of Microbiology and Immunology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    Search for more papers by this author
  • Joanne Kwak-Kim

    1. Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    2. Department of Microbiology and Immunology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    Search for more papers by this author

Joanne Kwak-Kim, MD, MPH, Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School/Rosalind Franklin University of Medicine and Science, 830 West End Ct, Suite 400, Vernon Hills, IL 60061, USA.
E-mail: Joanne.kwakkim@rosalindfranklin.edu

Abstract

Citation
Ahn H, Park J, Gilman-Sachs A, Kwak-Kim J. Immunologic characteristics of preeclampsia, a comprehensive review. Am J Reprod Immunol 2011; 65: 377–394

Preeclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality. Despite decades of intense research on the problem, there is no early pregnancy screening test to recognize those at risk. Recently, altered immune responses have been suspected to be involved in preeclampsia pathogenesis, which may involve the inflammatory context in which an immune response is mounted. In this review, the immunologic pathogenesis of the PE is reviewed in context of innate and adaptive immunity (both cellular, i.e., T and NK cells, and humoral immunity) in relation to thrombophilic conditions.

Ancillary