Pathophysiological Roles of Chemokines in Human Reproduction: An Overview
Version of Record online: 19 NOV 2010
© 2010 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Volume 65, Issue 5, pages 449–459, May 2011
How to Cite
Kitaya, K. and Yamada, H. (2011), Pathophysiological Roles of Chemokines in Human Reproduction: An Overview. American Journal of Reproductive Immunology, 65: 449–459. doi: 10.1111/j.1600-0897.2010.00928.x
- Issue online: 5 APR 2011
- Version of Record online: 19 NOV 2010
- Submitted July 20, 2010; accepted October 8, 2010.
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Citation Kitaya K, Yamada H. Pathophysiological Roles of Chemokines in Human Reproduction: An Overview. Am J Reprod Immunol 2011; 65: 449–459
Chemokines are a group of small cytokines that have an ability to induce leukocyte migration. Chemokines exert their functions by binding and activating specific G protein-coupled receptors. Studies have unveiled pleiotropic bioactivities of chemokines in various phenomena ranging from immunomodulation, embryogenesis, and homeostasis to pathogenesis. In the mammalian reproductive system, chemokines unexceptionally serve in multimodal events that are closely associated with establishment, maintenance, and deterioration of fecundity. The aim of this review is to update the knowledge on chemokines in male and female genital organs, with a focus on their potential pathophysiological roles in human reproduction.