The Role of the Foreskin in Male Circumcision: An Evidence-Based Review
Version of Record online: 28 NOV 2010
© 2010 John Wiley & Sons A/S
American Journal of Reproductive Immunology
Special Issue: Sexual Transmission of HIV in the 21st Century
Volume 65, Issue 3, pages 279–283, March 2011
How to Cite
Dinh, M. H., Fahrbach, K. M. and Hope, T. J. (2011), The Role of the Foreskin in Male Circumcision: An Evidence-Based Review. American Journal of Reproductive Immunology, 65: 279–283. doi: 10.1111/j.1600-0897.2010.00934.x
- Issue online: 7 FEB 2011
- Version of Record online: 28 NOV 2010
- Submitted October 16 2010; accepted October 19 2010.
Citation Dinh MH, Fahrbach KM, Hope TJ. The role of the foreskin in male circumcision: an evidence-based review. Am J Reprod Immunol 2011; 65: 279–283
HIV sexual transmission via the male genital tract remains poorly defined. Male circumcision was shown to reduce female-to-male transmission in Africa, providing a clue that the foreskin plays a role in the route of transmission. Scientific data in four categories relating to how the foreskin might affect HIV transmission is summarized: (i) surface area, (ii) microbiologic environment, (iii) HIV-1-susceptible cells, and (iv) tissue structure. The relative contribution of each of these areas is yet unknown, and further studies will be crucial in understanding how male circumcision affects HIV transmission in men.